Resolving the cholesterol controversy : the scientists who proved the lipid hypothesis of causation of atherosclerosis and coronary heart disease
- Gilbert R. Thompson.
- London ; Hackensack, NJ : World Scientific Publishing Europe Ltd, 
- Copyright notice
- Physical description
- xiv, 232 pages : illustrations (some color) ; 24 cm
- Thompson, G. R. (Gilbert R.), author.
- Includes bibliographical references and index.
- Introduction to the Lipid Hypothesis : the role of cholesterol in atherosclerosis
- Nikolai Anitschkow : The cholesterol-fed rabbit, an animal model of atherosclerosis
- John Gofman and Richard Havel : The discovery that cholesterol is transported by lipoproteins in the blood and their centrifugal analysis
- Thomas Dawber and William Kannel : The Framingham Study and risk factors for coronary heart disease
- Ancel Keys : The Seven Countries study and the role of dietary fat in determining cholesterol levels in populations
- Michael Oliver : Pros and cons of lowering cholesterol
- Donald Fredrickson and Robert Levy : The classification of disorders of lipoprotein metabolism
- John Yudkin : The role of sugar in coronary heart disease
- Sir John McMichael and J. R. Anthony Mitchell : Cardiological opponents of the lipid hypothesis
- Nicolas Myant : Familial Hypercholesterolaemia
- Joseph Goldstein and Michael Brown : Discovery of the LDL receptor
- Daniel Steinberg : The role of oxidised LDL in atherosclerosis
- Kåre Berg : Discovery of Lipoprotein (a)
- Gerd Utermann : Discovery of apoE isoforms and their role in lipid metabolism
- Akira Endo : The discovery of the first statin
- P. Roy Vagelos, Alfred Alberts and Jonathan Tobert : The development of statins for clinical use
- Terje Pedersen, James Shepherd and Sir Rory Collins : The statin trials that
- proved the lipid hypothesis
- Impact of proof of the lipid hypothesis on the science and practice of Medicine
- The future of clinical lipidology.
- "This book recounts the science and scientific personalities behind the chain of discoveries upon which the lipid hypothesis of atherosclerosis was built. The narrative covers a period of just under a hundred years, starting with Anitschkow's experiments with cholesterol-fed rabbits in 1913, and recounts the endeavours and achievements of the leading actors in this protracted scientific drama. The cast includes an extraordinarily wide variety of scientific disciplines: pathology, biophysics, epidemiology, nutrition, cardiology, lipidology, genetics; microbiology, pharmacology, and clinical trial design. Most of the scientists believed that cholesterol played a causal role in atherosclerosis and cardiovascular disease but there were some who dissented strongly from this conclusion. The breadth of scientific disciplines involved in proving the lipid hypothesis is matched by the geographical spread of the participants. Anitschkow worked in Russia, Endo discovered the first statin in Japan, their commercial development by Merck took place in the USA and evidence of benefit from lowering cholesterol came from trials conducted in Scandinavia and the UK. The subsequent meta-analysis of these statin trials in 2005 proved the validity of the lipid hypothesis beyond any doubt, and the history of how this all came about and its impact upon health policy and medical practice is recalled here in Resolving the Cholesterol Controversy"-- Provided by publisher.
- Publication date
- 9781800613973 hardcover
- 1800613970 hardcover
- 9781800613980 electronic book for institutions
- 9781800613997 electronic book for individuals
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