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• Part I: Foundations.- Introduction.- Genetic Algorithms.- Parameters.- Part II: Solution Spaces.- Multimodality.- Constraints.- Multiple Objectives.- Part III: Advanced Concepts.- Theory.- Machine Learning.- Applications.- Part IV: Ending.- Summary and Outlook.- Index.- References.
• (source: Nielsen Book Data)

This book introduces readers to genetic algorithms (GAs) with an emphasis on making the concepts, algorithms, and applications discussed as easy to understand as possible. Further, it avoids a great deal of formalisms and thus opens the subject to a broader audience in comparison to manuscripts overloaded by notations and equations. The book is divided into three parts, the first of which provides an introduction to GAs, starting with basic concepts like evolutionary operators and continuing with an overview of strategies for tuning and controlling parameters. In turn, the second part focuses on solution space variants like multimodal, constrained, and multi-objective solution spaces. Lastly, the third part briefly introduces theoretical tools for GAs, the intersections and hybridizations with machine learning, and highlights selected promising applications.
(source: Nielsen Book Data)

• Part I Foundations
• Part II Advanced Optimization
• Part III Learning
• Part IV Appendix.

Practical optimization problems are often hard to solve, in particular when they are black boxes and no further information about the problem is available except via function evaluations. This work introduces a collection of heuristics and algorithms for black box optimization with evolutionary algorithms in continuous solution spaces. The book gives an introduction to evolution strategies and parameter control. Heuristic extensions are presented that allow optimization in constrained, multimodal, and multi-objective solution spaces. An adaptive penalty function is introduced for constrained optimization. Meta-models reduce the number of fitness and constraint function calls in expensive optimization problems. The hybridization of evolution strategies with local search allows fast optimization in solution spaces with many local optima. A selection operator based on reference lines in objective space is introduced to optimize multiple conflictive objectives. Evolutionary search is employed for learning kernel parameters of the Nadaraya-Watson estimator, and a swarm-based iterative approach is presented for optimizing latent points in dimensionality reduction problems. Experiments on typical benchmark problems as well as numerous figures and diagrams illustrate the behavior of the introduced concepts and methods.

• Foundations. K-Nearest Neighbors
• Ensemble Learning
• Dimensionality Reduction
• Unsupervised Nearest Neighbors. Latent Sorting
• Metaheuristics
• Kernel and Submanifold Learning
• Conclusions. Summary and Outlook.

This book is devoted to a novel approach for dimensionality reduction based on the nearest neighbor method, a powerful classification and regression approach.

• I: Foundations of Evolutionary Computation.- Evolutionary Algorithms.- Self-Adaptation.- II: Self-Adaptive Operators.- Biased Mutation for Evolution Strategies.- Self-Adaptive Inversion Mutation.- Self-Adaptive Crossover.- III: Constraint Handling.- Constraint Handling Heuristics for Evolution Strategies.- IV: Summary.- Summary and Conclusion.- V: Appendix.- Continuous Benchmark Functions.- Discrete Benchmark Functions.
• (source: Nielsen Book Data)

Evolutionary algorithms are successful biologically inspired meta-heuristics. Their success depends on adequate parameter settings. The question arises: how can evolutionary algorithms learn parameters automatically during the optimization? Evolution strategies gave an answer decades ago: self-adaptation. Their self-adaptive mutation control turned out to be exceptionally successful. But nevertheless self-adaptation has not achieved the attention it deserves. This book introduces various types of self-adaptive parameters for evolutionary computation. Biased mutation for evolution strategies is useful for constrained search spaces. Self-adaptive inversion mutation accelerates the search on combinatorial TSP-like problems. After the analysis of self-adaptive crossover operators the book concentrates on premature convergence of self-adaptive mutation control at the constraint boundary. Besides extensive experiments, statistical tests and some theoretical investigations enrich the analysis of the proposed concepts.
(source: Nielsen Book Data)

• Analyzing Lymphoma Development and Progression Using HDACi in Mouse Models
• Colony Formation Assay to Test the Impact of HDACi on Leukemic Cells
• Defined Human Leukemic CD34+ Liquid Cultures to Study HDAC/Transcriptional Repressor Complexes
• Development of a Cellular Model Mimicking Specific HDAC Inhibitors
• Evaluation of Anti-Tumor and On-Target Activity of HDAC Inhibitors with the Zebrafish Embryo Xenograft Model
• Human Platelet Lysate as Valid Cell Growth Additive to Assess Protein Acetylation
• Investigating Physiopathological Roles for Sirtuins in a Mouse Model
• Patient-Derived Organoids for In Vivo Validation of In Vitro Data
• Analysis of HDACi-Coupled Nanoparticles: Opportunities and Challenges
• Development of Pyrazine-Anilinobenzamides as Histone Deacetylase HDAC1-3 Selective Inhibitors and Biological Testing Against Pancreas Cancer Cell Lines
• Evaluation of Small Molecule HDAC Inhibitors through In Vitro and In Cellulo Approaches
• Synthesis, Biochemical, and Cellular Evaluation of HDAC6 Targeting Proteolysis Targeting Chimeras
• HDACi Delivery Systems Based on Cellulose Valproate Nanoparticles
• Synthesis and Characterization of Reversible Covalent HDAC4 Inhibitors
• Analysis of Cell Cycle and DNA Compaction Dependent Subnuclear Distribution of Histone Marks
• Analyzing the Effects of HDAC Inhibitors on DNA Damage and Associated Cytotoxicity in Primary Hepatocytes
• Assessment of HDAC Inhibitor-Induced Endoplasmic Reticulum (ER) Stress
• Assessment of Mitochondrial Dysfunctions after Sirtuin Inhibition
• Assessing the Effect of Histone Deacetylase Inhibitors on DNA Double-Strand Break Repair by Non-Homologous End Joining
• Assessing SIRT7 Activity In Vivo and In Vitro in Response to DNA Damage
• Methods to Evaluate the Effects of HAT/KAT Inhibition on SIAH2-Driven Reactive Oxygen Species Generation in Helicobacter pylori-Infected Gastric Epithelial Cells
• Monitoring Changes in Intracellular Reactive Oxygen Species Levels in Response to Histone Deacetylase Inhibitors
• Single-Cell Analysis of Histone Acetylation Dynamics at Replication Forks Using PLA and SIRF
• Testing the Effect of Histone Acetyltransferases on Local Chromatin Compaction
• A Genome-Wide CRISPR-Cas9 Loss-of-Function Screening to Identify Host Restriction Factors Modulating Oncolytic Virotherapy
• Cloning Strategy for HDAC1/HDAC2 Hybrid Protein Expression in Mammalian Cells
• Continuous Histone Deacylase Activity Assays
• CRISPR Activation/Interference Screen to Identify Genetic Networks in HDAC-Inhibitor Resistant Cells
• Determining Potency of Inhibitors Targeting Histone Deacetylase 6 by Quantification of Acetylated Tubulin in Cells
• Expression and Crystallization of HDAC6 Tandem Catalytic Domains
• Fluorescence Polarization-Based Competition Assays to Evaluate Histone Deacetylase 6 Inhibitors
• Immunoprecipitation of HDAC6 and Interacting Proteins.

This fully updated edition provides a series of methods for how best to assess functions of histone deacetylases and acetyltransferases. The disease-relevance of dysregulated protein deacetylation by overexpressed or aberrantly activated histone deacetylases has spurred an intense search for novel and improved inhibitors of these enzymes, as reflected in this collection. Expert contributors explore the generation and evaluation of novel histone deacetylase inhibitors and new and improved techniques to assess acetylation-dependent molecular mechanisms in vitro and in vivo. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, HDAC/HAT Function Assessment and Inhibitor Development: Methods and Protocols, Second Edition serves as an ideal guide for researchers seeking to further elucidate this vital area of study.

• Part I: Analysis of Cellular Processes that Are Regulated by HDACs
• 1. Detection of Autophagy Induction After HDAC Inhibitor Treatment in Leukemic Cells Anja Goder, Nisintha Mahendrarajah, and Oliver H. Kramer
• 2. Assessment of HDACi-Induced Protein Cleavage by Caspases Fabian Treude, Tobias Gladbach, Jacqueline Plaster, and Jorg Hartkamp
• 3. Assessment of HDACi-Induced Cytotoxicity Lisa Blumel, Christian Marx, Marie Kuhne, and Jurgen Sonnemann
• 4. Analysis of HDACi-Induced Changes in Chromosomal Passenger Complex Localization Britta Unruhe-Knauf and Shirley K. Knauer
• 5. Analysis of Histone Deacetylase-Dependent Effects on Cell Migration Using the Stripe Assay Sonja Mertsch and Solon Thanos
• 6. Using Histone Deacetylase Inhibitors to Analyze the Relevance of HDACs for Translation Darren M. Hutt, Daniela Martino Roth, Christelle Marchal, and Marion Bouchecareilh
• 7. Effects of HDACi on Immunological Functions Rene Winkler and Christian Kosan
• 8. DNA Fiber Spreading Assay to Test HDACi Effects on DNA and Its Replication Teodora Nikolova, Anja Goder, Ann Parplys, and Kerstin Borgmann
• 9. Assessing the Effect of Class I Histone Deacetylase Activity on DNA Double-Strand Break Repair by Homologous Recombination Andrea Krumm and Wynand P. Roos
• Part II: Primary Cell Systems and In Vivo Models to Assess HDAC Functions
• 10. Establishment and Characterization of Long-Term Cultures Derived from Primary Acute Myeloid Leukemia Cells for HDAC Inhibitor Research Annette Romanski and Gesine Bug
• 11. Assessing the Histone Deacetylase Activity of SIRT6 in Primary Murine Hepatocytes Via Proximity Ligation Assay Katharina Wolf and Susanne Strand
• 12. Purification and Analysis of Male Germ Cells from Adult Mouse Testis Thierry Buchou, Minjia Tan, Sophie Barral, Anne-Laure Vitte, Sophie Rousseaux, Juan Arechaga, and Saadi Khochbin
• 13. Generation of Tissue-Specific Mouse Models to Analyze HDAC Functions Astrid Hagelkruys, Mirjam A. Moser, and Christian Seiser
• 14. Engineering of Conditional Class I Hdac Knockout Mice and Generation of a Time-Spatial Knockout by a Dual Recombination System Sieglinde Bayer and Matthias Wirth
• 15. Xenografting of Cancer Cell Lines for In Vivo Screening of the Therapeutic Potential of HDAC Inhibitors Daniel Nettersheim, Sina Jostes, and Hubert Schorle
• 16. Generation of Xenotransplants from Human Cancer Biopsies to Assess Anti-Cancer Activities of HDACi Christina Susanne Mullins, Stephanie Bock, Mathias Krohn, and Michael Linnebacher
• Part III: Assessment of HDAC-Dependent Effects on Signaling Cascades in Primary and Permanent Cells
• 17. Phospho-Flow Analysis of Primary Mouse Cells after HDAC Inhibitor Treatment Dagmar Hildebrand and Katharina F. Kubatzky
• 18. Evaluation of Innate Immune Gene Expression Following HDAC Inhibitor Treatment by High Throughput qPCR and PhosFlow Cytometry David Olagnier, Cindy Chiang, and John Hiscott
• 19. Assessing HDAC Function in the Regulation of Signal Transducer and Activator of Transcription 5 (STAT5) Activity Using Chromatin Immunoprecipitation (ChIP) Sophia Pinz and Anne Rascle
• 20. Modulation of STAT1-Driven Transcriptional Activity by Histone Deacetylases Benjamin Y. Owusu and Lidija Klampfer
• 21. Proximity Ligation Assay to Quantify Foxp3 Acetylation in Regulatory T Cells Jing Jiao, Rongxiang Han, Wayne W. Hancock, and Ulf H. Beier
• Part IV: PTMs Controlling Acetylation Balances and HDAC Functions
• 22. Testing the Effects of SIAH Ubiquitin E3 Ligases on Lysine Acetyl Transferases Jan Hagenbucher, Hilda Stekman, Alfonso Rodriguez-Gil, Michael Kracht, and M. Lienhard Schmitz
• 23. Assessment of HDACi-Induced Acetylation of Non-Histone Proteins by Mass Spectrometry Martin Wieczorek, Karl-Heinz Guhrs, and Thorsten Heinzel
• 24. Assessing the Role of Paralog-Specific Sumoylation of HDAC1 Simona Citro and Susanna Chiocca
• 25. Analysis of Histone Deacetylases Sumoylation by Immunoprecipitation Techniques Tobias Wagner, Maren Godmann, and Thorsten Heinzel
• Part V: Improved, Novel, and Specific HDACi
• 26. How to Distinguish Between the Activity of HDAC1-3 and HDAC6 with Western Blot Mandy Beyer, Nicole Kiweler, Siavosh Mahboobi, and Oliver H. Kramer
• 27. Evaluating the Effect of HDAC8 Inhibition in Malignant Peripheral Nerve Sheath Tumors Gonzalo Lopez and Raphael E. Pollock
• 28. Analyzing the Impact of Pan- and Class-Specific HDACi on Differentiation-Associated Factors Katrin Noack and Oliver H. Kramer
• 29. Encapsulation of the HDACi Ex527 into Liposomes and Polymer-Based Particles Dorle Hennig and Diana Imhof
• 30. Preparation of Histone Deacetylase Inhibitor Vorinostat Loaded Poly d, l-lactide-co-glycolide Polymeric Nanoparticles by Nanoprecipitation Method Vilwanathan Ravikumar and Renu Sankar "br> 31. Generation and Assessment of Fusions Between HDACi and TKi Siavosh Mahboobi, Bernadette Pilsl, and Andreas Sellmer.
• (source: Nielsen Book Data)

This detailed collection covers how the biological functions of histone deacetylases (HDACs) and histone acetyltransferases (HATs) can be detected in various experimental settings, both in vivo and in vitro. The book also covers the generation and specificity of deacetylase inhibitors and how such agents can be used to test experimental hypotheses. Written for the popular Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, HDAC/HAT Function Assessment and Inhibitor Development: Methods and Protocols serves as an ideal guide to this vital area of study.
(source: Nielsen Book Data)

• Musikpädagogik und Ethnomusikoiogie im Diskurs : eine Einführung / Barbara Alge, Oliver Krämer
• Children, Teachers, and Ethnomusicologists : Traditions and Transformations of Music in Schools / Patricia Shehan Campbell
• Hören und Verstehen
• Hören und Verstehen im interkulturellen Kontext / Max Peter Baumann
• Hören und Verstehen aus musikpädagogischer Perspektive : ein historischer Überblick anhand von neun Blitzlichtern / Oliver Krämer
• Diversität und Identität
• Hör ich verschieden oder hören wir gleich? : zur Bedeutung der Begriffe "Diversität" und "Identität" in der Interkulturellen Musikpädagogik / Dorothee Barth
• Identität und Diversität in der Musikethnologie / Raimund Vogels
• Authentizität und Adaption
• Undoing Authenticity as a Discursive Construct : a Critical Pedagogy of Ethnomusicology and "World Music" / Simone Krüger
• Authentizität und Adaption : Aspekte interkultureller Musikerziehung : Rückblick und Ausblick / Irmgard Merkt
• Distanz und Involviertheit
• Musik(pädagogik) im Kaleidoskop der Weltkulturen / Magnus Gaul
• Von der Feldforschung ins Klassenzimmer : Reflexive Ethnografie und ihre Relevanz für die Musikpädagogik / Barbara Alge
• Geschichtlichkeit und Globalisierung
• Musiktraditionen im Kontext moderner Clobalisierungsprozesse und globaler Denkkonzepte / Britta Sweers
• Zeitliche und räumliche Grenzüberschreitungen in der Musikpädagogik / Alexander J. Cvetko
• Inhalte und Methoden
• Musiken im Musikunterricht : das Problem des Exemplarischen / Bernd Clausen
• Zeigen, Tun, Recherchieren, Feiern : Methodische Herzstücke einer Welt-Musik-Pädagogik / Isolde Malmberg
• Nachwort
• Musikpädagogik und Ethnomusikologie im Diskurs : Ergebnisse und Ausblick / Barbara Alge, Oliver Krämer
• Anhang
• Glossar zentraler Begriffe
• Autorinnen und Autoren.

• Locating Faults in Photovoltaic Systems Data.- Forecasting of Smart Meter Time Series Based on Neural Cybersecurity for Smart Cities: A Brief Review.- Machine Learning Prediction of Photovoltaic Energy from Satellite Sources.- Approximate Probabilistic Power Flow.- Dealing with Uncertainty: An Empirical Study on the Relevance of Renewable Energy Forecasting Methods.- Measuring Stakeholders' Perceptions of Cybersecurity for Renewable Energy Systems.- Selection of Numerical Weather Forecast Features for PV Power Predictions with Random Forests.- Evolutionary Multi-Objective Ensembles for Wind Power Prediction.- A Semi-Automatic Approach for Tech Mining and Interactive Taxonomy Visualization.- Decomposition of Aggregate Electricity Demand into the Seasonal-Thermal Components for Demand-Side Management Applications in "Smart Grids".
• (source: Nielsen Book Data)

This book constitutes revised selected papers from the 4th ECML PKDD Workshop on Data Analytics for Renewable Energy Integration, DARE 2016, held in Riva del Garda, Italy, in September 2016. The 11 papers presented in this volume were carefully reviewed and selected for inclusion in this book and handle topics such as time series forecasting, the detection of faults, cyber security, smart grid and smart cities, technology integration, demand response and many others.
(source: Nielsen Book Data)

• Imitative learning for online planning in microgrids.- A novel central voltage-control strategy for smart LV distribution networks.- Quantifying energy demand in mountainous areas.- Performance analysis of data mining techniques for improving the accuracy of wind power forecast combination.- Evaluation of forecasting methods for very small-scale networks.- Classification cascades of overlapping feature ensembles for energy time series data.- Correlation analysis for determining the potential of home energy management systems in Germany.- Predicting hourly energy consumption. Can regression modeling improve on an autoregressive baseline.- An OPTICS clustering-based anomalous data filtering algorithm for condition monitoring of power equipment.- Argument visualization and narrative approaches for collaborative spatial decision making and knowledge construction: A case study for an offshore wind farm project.
• (source: Nielsen Book Data)

This book constitutes revised selected papers from the 5th ECML PKDD Workshop on Data Analytics for Renewable Energy Integration, DARE 2017, held in Skopje, Macedonia, in September 2017. The 11 papers presented in this volume were carefully reviewed and selected for inclusion in this book and handle topics such as time series forecasting, the detection of faults, cyber security, smart grid and smart cities, technology integration, demand response and many others.
(source: Nielsen Book Data)

• Musik und Schweigen
• Krieger und Musiker : Geschichte(n) verändern / Christine Dettmann
• Die Musiktraditionen der syrischen liturgischen Riten / Mäher Farkouh
• "-- vor neuralgischen Schmerzen nicht schlafen" : zur pädagogischen Relevanz einer vergessenen Hymne / Bernd Fröde
• Faust-Symhonie, oder : das Streben nach mehr / Magnus Gaul
• Weltliche Liederbücher des 15. und 16. Jahrhunderts : zur Beschreibung eines literarisch-musikalischen Diskurses im deutschsprachigen Spätmittelalter / Franz-Josef Holznagel
• Das spürbar Spannende einer spannungsvollen Musik : Publikumsbezogene Analysen ausgewählter Lieder Herbert Grönemeyers / Florian Koeppe
• Dmitri Schostakowitschs Lady Macbeth heute / Hartmut Möller
• Vom beredten Schweigen / Elke Pahn
• Musikalität : nur ein neuronales Netzwerk im Gehirn? / Nicolai Petrat
• Shofar Gadol : Jüdische Musik auf dem Schweizer Nationalinstrument / Sarah M. Ross
• Einladung zum Treffpunkt Spielbaum / Karla Schöne
• 'Gaelic Psalm Singing' im Prozess musikalischer Hybridisierung / Martin Schröder
• Beethovens Form und Formenlehre : Überlegungen zum 1. Satz der Klaviersonate op. 10/2 / Jan Philipp Sprick
• Grenzgänge : der Kopfsatz der Erstfassung des Klaviertrios H-Dur op. 8 von Johannes Brahms / Walter Werbeck
• Künste und Grenzen
• Theater als Ort der Begegnung : das Ich und der Andere " Intersubjektivität und Empathie im schauspielerischen Prozess / Enrico De Feo
• "-- physical sculptures through time and space --" : Stimme, Klang und Erfahrungsraum bei Janet Cardiff / Stefan Drees
• Was sucht Francesco Petrarca in der Franziskanerbibliothek von St. Katharinen in Rostock? / Frank Ivemeyer
• Film, Musik, Diaspora : Musikalische Entgrenzungen in Mira Nairs Salaam Bombay / Gabriele Linke
• Grenzüberschreitungen im künstlerischen und wissenschaftlichen Schaffen von Otto Laske / Nico Schüler
• Die Neugier ist der Ton der Katze -- : Virtuosität im Werk Cory Arcangels / Nadine Söll
• Wissenschaft und Austausch
• Zur Positionierung der Ethnomusikologie im Kontext einer Relationalen Musikwissenschaft an Musikhochschulen / Barbara Alge
• Warum Musikwissenschaft und Musikpädagogik einander brauchen : eine Skizze gegenseitigen Bedarfs / Oliver Krämer
• Musikwissenschaftliche Grenzgänge zwischen Inner- und Inter - disziplinarität : Gedanken zur Integration neuer Schwerpunkte / Britta Sweers
• Kontakt und Freundschaft
• Begegnungen / Hikmat Al-Sabty
• 60 Jahre und ein bisschen weise / Silvio Dalla Torre
• 10 Geburtstagsblätter für Hartmut Möller (2012), Nr.1 / Adriana Hölszky
• Grenzenlos / Renate Kafiirke
• Polyphone Musikgeschichtsschreibung : Hartmut Möller im Gespräch / Andreas Möllenkamp
• Verzeichnisse
• Schriftenverzeichnis
• Betreute Dissertationen und Habilitationen
• Die Autorinnen und Autoren.