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• 1. Pharmaceutical prospects of plant-based bioactive molecules
• 2. Utilization of plants and their different portions for the extraction of bioactive phytochemicals and their high throughput screening techniques
• 3. Conventional approaches for the extraction of bioactive compounds for pharmaceutical applications
• 4. Advancement in bioactive compound extraction from natural products for pharmaceutical applications
• 5. Neoteric solvents for extraction of bioactive phytochemicals
• 6. Application and effectiveness of computational methods in improving the production of bioactive phytochemicals
• 7. Advances in encapsulation strategies for bioactive phytochemicals
• 8. Applications of herb-derived bioactive phytochemicals
• 9. Pharmacological and therapeutic aspects of various medicinal plants
• 10. Applications of plant-derived metal nanoparticles in pharmaceuticals
• 11. Patents on naturally derived pharmaceuticals.
• (source: Nielsen Book Data)

Advances in Extraction and Applications of Bioactive Phytochemicals presents comprehensive and systematic coverage of extraction techniques for bioactive phytochemical compounds and their delivery and therapeutic effectiveness. Sections focus on the pharmaceutical industry's perspective, aiming at compiling recent advances of natural products in the field of drug delivery, including a brief overview of plant-based bioactive molecules, utilization of different plant elements for the extraction of phytochemicals, a compilation of conventional extraction approaches, advanced extraction methods, including Supercritical carbon-dioxide extraction, computational methods to improve production, drug delivery aspects of bioactive phytochemicals, their therapeutic effectiveness, and more. This book is a complete reference targeted at pharma researchers in academic and corporate environments and those willing to apply the most current extraction methods and health applications. Researchers in medicinal chemistry and chemical engineering will also benefit from this comprehensive resource.
(source: Nielsen Book Data)

Antimicrobial resistance is recognised among the worlds most challenging problems. Despite its global spread, Africa, specifically sub-Saharan Africa, is the most affected by this malaise. Poor living conditions and inadequate access to sanitation and potable water supplies are among contributing factors that have influenced a high disease burden on the continent, requiring extensive antimicrobials. Weak health systems and the absence of firm policies further aggravate the problem, as the use of antimicrobials is mostly unregulated. The increasing demand for animal protein to meet the starving populations demands has also influenced the use of these antimicrobials, including those banned on other continents, for food animal production. The ripple effect of indiscriminate use in humans and animals is the massive discharge of antimicrobials, their residues, antimicrobial-resistant microorganisms and their associated genes into the environment. This 14-chapter text presents the AMR problem in African, addressing the various compartments of One Health humans, animals, and the environment, to illustrate the need for concerted efforts in the fight against AMR. Authors from the four cardinal points present diverse aspects of AMR in Africa, starting with behavioural and social drivers of AMR in Africa. Antimicrobial stewardship in an African context is also discussed. AMR in humans is presented through studies on antibiotic-resistant neonates and nontyphoidal Salmonella infections and the clinical relevance of the genetics of viral resistance. Topics on AMR in mastitis, biosecurity in animal farming and the linkage between disinfectants and AMR are discussed. The environmental dimension of AMR is discussed, notably in the aquatic environment, and its implication for aquaculture and irrigation and using nanomaterials to treat polluted waters from such environments are highlighted. Finally, Africas rich floral diversity is portrayed as an eco-friendly and cost-effective approach to combat AMR. Hopefully, the work presented will spur greater collaboration between scientists, environmental, animal and human health practitioners, the general population, and policymakers to assimilate and implement the One Health approach to combating AMR, rather than working in silos in their various sectors.

• BIOINFORMATICS TOOLS. Introduction to Bioinformatics, AI, and ML for Pharmaceuticals / Vivek P Chavda, Disha Vihol, Aayushi Patel, Elrashdy M Redwan, Vladimir N Uversky
• Artificial Intelligence and Machine Learning-Based New Drug Discovery Process with Molecular Modelling / Isha Rani, Kavita Munjal, Rajeev K Singla, Rupesh K Gautam
• Role of Bioinformatics in Peptide-Based Drug Design and Its Serum Stability / Vivek Chavda, Prashant Kshirsagar, Nildip Chauhan
• Data Analytics and Data Visualization for the Pharmaceutical Industry / Shalin Parikh, Ravi Patel, Dignesh Khunt, Vivek P Chavda, Lalitkumar Vora
• Mass Spectrometry, Protein Interaction and Amalgamation of Bioinformatics / Vivek Chavda, Kaustubh Dange, Madhav Joglekar
• Applications of Bioinformatics Tools in Medicinal Biology and Biotechnology / Harshil Shah, Vivek Chavda, Moinuddin M Soniwala
• Clinical Applications of "Omics" Technology as a Bioinformatic Tool / Vivek Chavda, Rajashri Bezbaruah, Disha Valu, Sanjay Desai, Nildip Chauhan, Swati Marwadi, Gitima Deka, Zhiyong Ding
• BIOINFORMATICS TOOLS FOR PHARMACEUTICAL SECTOR. Bioinformatics and Cheminformatics Tools in Early Drug Discovery / Palak K Parikh, Jignasa K Savjani, Anuradha K Gajjar, Mahesh T Chhabria
• Artificial Intelligence and Machine Learning-Based Formulation and Process Development for Drug Products / Vivek P Chavda
• Artificial Intelligence and Machine Learning-Based Manufacturing and Drug Product Marketing / Kajal Baviskar, Anjali Bedse, Shilpa Raut, Narayana Darapaneni
• Artificial Intelligence and Machine Learning Applications in Vaccine Development / Ali Sarmadi, Majid Hassanzadeganroudsari, M Soltani
• AI, ML and Other Bioinformatics Tools for Preclinical and Clinical Development of Drug Products / Avinash Khadela, Sagar Popat, Jinal Ajabiya, Disha Valu, Shrinivas Savale, Vivek P Chavda
• BIOINFORMATICS TOOLS FOR HEALTHCARE SECTOR. Artificial Intelligence and Machine Learning in Healthcare Sector / Vivek P Chavda, Kaushika Patel, Sachin Patel, Vasso Apostolopoulos
• Role of Artificial Intelligence in Machine Learning for Diagnosis and Radiotherapy / Sanket Chintawar, Vaishnavi Gattani, Shivanee Vyas, Shilpa Dawre
• Role of AI and ML in Epidemics and Pandemics / Rajashri Bezbaruah, Mainak Ghosh, Shuby Kumari, Lawandashisha Nongrang, Sheikh Rezzak Ali, Monali Lahiri, Hasmi Waris, Bibhuti Bhushan Kakoti
• AI and ML for Development of Cell and Gene Therapy for Personalized Treatment / Susmit Mhatre, Somanshi Shukla, Vivek P Chavda, Lakshmikanth Gandikota, Vandana Patravale
• Future Prospects and Challenges in the Implementation of AI and ML in Pharma Sector / Prashant Pokhriyal, Vivek P Chavda, Mili Pathak.

BIOINFORMATICS TOOLS FOR Pharmaceutical DRUG PRODUCT DLEVELOPMENT A timely book that details bioinformatics tools, artificial intelligence, machine learning, computational methods, protein interactions, peptide-based drug design, and omics technologies, for drug development in the pharmaceutical and medical sciences industries. The book contains 17 chapters categorized into 3 sections. The first section presents the latest information on bioinformatics tools, artificial intelligence, machine learning, computational methods, protein interactions, peptide-based drug design, and omics technologies. The following 2 sections include bioinformatics tools for the pharmaceutical sector and the healthcare sector. Bioinformatics brings a new era in research to accelerate drug target and vaccine design development, improving validation approaches as well as facilitating and identifying side effects and predicting drug resistance. As such, this will aid in more successful drug candidates from discovery to clinical trials to the market, and most importantly make it a more cost-effective process overall. Readers will find in this book: Applications of bioinformatics tools for pharmaceutical drug product development like process development, pre-clinical development, clinical development, commercialization of the product, etc.; The ever-expanding application of this novel technology and discusses some of the unique challenges associated with such an approach; The broad and deep background, as well as updates, on recent advances in both medicine and AI/ML that enable the application of these cutting-edge bioinformatics tools. Audience The book will be used by researchers and scientists in academia and industry including drug developers, computational biochemists, bioinformaticians, immunologists, pharmaceutical and medical sciences, as well as those in artificial intelligence and machine learning.

• BIOINFORMATICS TOOLS. Introduction to Bioinformatics, AI, and ML for Pharmaceuticals / Vivek P Chavda, Disha Vihol, Aayushi Patel, Elrashdy M Redwan, Vladimir N Uversky
• Artificial Intelligence and Machine Learning-Based New Drug Discovery Process with Molecular Modelling / Isha Rani, Kavita Munjal, Rajeev K Singla, Rupesh K Gautam
• Role of Bioinformatics in Peptide-Based Drug Design and Its Serum Stability / Vivek Chavda, Prashant Kshirsagar, Nildip Chauhan
• Data Analytics and Data Visualization for the Pharmaceutical Industry / Shalin Parikh, Ravi Patel, Dignesh Khunt, Vivek P Chavda, Lalitkumar Vora
• Mass Spectrometry, Protein Interaction and Amalgamation of Bioinformatics / Vivek Chavda, Kaustubh Dange, Madhav Joglekar
• Applications of Bioinformatics Tools in Medicinal Biology and Biotechnology / Harshil Shah, Vivek Chavda, Moinuddin M Soniwala
• Clinical Applications of "Omics" Technology as a Bioinformatic Tool / Vivek Chavda, Rajashri Bezbaruah, Disha Valu, Sanjay Desai, Nildip Chauhan, Swati Marwadi, Gitima Deka, Zhiyong Ding
• BIOINFORMATICS TOOLS FOR PHARMACEUTICAL SECTOR. Bioinformatics and Cheminformatics Tools in Early Drug Discovery / Palak K Parikh, Jignasa K Savjani, Anuradha K Gajjar, Mahesh T Chhabria
• Artificial Intelligence and Machine Learning-Based Formulation and Process Development for Drug Products / Vivek P Chavda
• Artificial Intelligence and Machine Learning-Based Manufacturing and Drug Product Marketing / Kajal Baviskar, Anjali Bedse, Shilpa Raut, Narayana Darapaneni
• Artificial Intelligence and Machine Learning Applications in Vaccine Development / Ali Sarmadi, Majid Hassanzadeganroudsari, M Soltani
• AI, ML and Other Bioinformatics Tools for Preclinical and Clinical Development of Drug Products / Avinash Khadela, Sagar Popat, Jinal Ajabiya, Disha Valu, Shrinivas Savale, Vivek P Chavda
• BIOINFORMATICS TOOLS FOR HEALTHCARE SECTOR. Artificial Intelligence and Machine Learning in Healthcare Sector / Vivek P Chavda, Kaushika Patel, Sachin Patel, Vasso Apostolopoulos
• Role of Artificial Intelligence in Machine Learning for Diagnosis and Radiotherapy / Sanket Chintawar, Vaishnavi Gattani, Shivanee Vyas, Shilpa Dawre
• Role of AI and ML in Epidemics and Pandemics / Rajashri Bezbaruah, Mainak Ghosh, Shuby Kumari, Lawandashisha Nongrang, Sheikh Rezzak Ali, Monali Lahiri, Hasmi Waris, Bibhuti Bhushan Kakoti
• AI and ML for Development of Cell and Gene Therapy for Personalized Treatment / Susmit Mhatre, Somanshi Shukla, Vivek P Chavda, Lakshmikanth Gandikota, Vandana Patravale
• Future Prospects and Challenges in the Implementation of AI and ML in Pharma Sector / Prashant Pokhriyal, Vivek P Chavda, Mili Pathak.

BIOINFORMATICS TOOLS FOR Pharmaceutical DRUG PRODUCT DLEVELOPMENT A timely book that details bioinformatics tools, artificial intelligence, machine learning, computational methods, protein interactions, peptide-based drug design, and omics technologies, for drug development in the pharmaceutical and medical sciences industries. The book contains 17 chapters categorized into 3 sections. The first section presents the latest information on bioinformatics tools, artificial intelligence, machine learning, computational methods, protein interactions, peptide-based drug design, and omics technologies. The following 2 sections include bioinformatics tools for the pharmaceutical sector and the healthcare sector. Bioinformatics brings a new era in research to accelerate drug target and vaccine design development, improving validation approaches as well as facilitating and identifying side effects and predicting drug resistance. As such, this will aid in more successful drug candidates from discovery to clinical trials to the market, and most importantly make it a more cost-effective process overall. Readers will find in this book: Applications of bioinformatics tools for pharmaceutical drug product development like process development, pre-clinical development, clinical development, commercialization of the product, etc.; The ever-expanding application of this novel technology and discusses some of the unique challenges associated with such an approach; The broad and deep background, as well as updates, on recent advances in both medicine and AI/ML that enable the application of these cutting-edge bioinformatics tools. Audience The book will be used by researchers and scientists in academia and industry including drug developers, computational biochemists, bioinformaticians, immunologists, pharmaceutical and medical sciences, as well as those in artificial intelligence and machine learning.

• The whistleblower
• The sellers
• Mormon country, U.S.A.
• The blood of our youth
• Moving blood
• The vampires of capitalism
• Vanity and blood
• Hollowed out and never enough
• The rust in our veins
• Flint
• The father of blood banking
• Crime, punishment, and plasma
• Borderlands
• A battle for blood on the border
• The blood givers' union
• What to do about the giant pool

"Bad Blood meets Dreamland in this kaleidoscopic investigation into the shadowy and vampiric blood business and the dangerous limits of demand for the crucial resource that runs through our very veins. Every year, about twenty million Americans sell blood plasma for cash in a barely regulated market dominated by private industry and off-the-grid trafficking. These commercial efforts prey on an insatiable market for medical and scientific innovation fed from the veins of some of the country's most marginalized communities, such as undocumented immigrants and residents of poverty-stricken Flint, Michigan. We are often told that "blood donations" are used to save lives, but blood plasma, a component of whole blood, has become a precious commercial good. Blood plasma is collected and marketed by private industry, with the United States one of just five nations on the planet that have not yet banned the practice of pay-for-plasma giving. This precious resource is used for everything from expensive and unproven age-reversing treatments to costly and experimental cures for novel diseases like COVID-19. Based on a cross-country investigation into the plasma-giving capitals of the country, in-depth research into the blood industry, and her personal experience as a beneficiary of plasma-derived treatment for a rare condition, Kathleen McLaughlin's Blood Money reveals the underhanded machinations and unbalanced power structures of the blood industry. Taking us from China's blood black market to Silicon Valley's shadowy tech startups, this is an unforgettable inside look at an industry many of us had no idea even existed. Blood Money is an electrifying exposé that demonstrates the shadowy overlap between big medicine and big business and paints a searing portrait of the extent to which American industry feeds on the country's most vulnerable"-- Provided by publisher

"This highly illustrated introductory text helps you learn and retain key information in pharmacology--taking you from course exams and the USMLE Step 1 right through to clinical practice"-- publisher's description.

Hallucinogenic drugs, popularly called psychedelics, have been used by human societies for thousands of years. Today, scientists are taking a second look at many of these mind-altering substances, both natural and synthetic, and discovering that they can have profoundly positive clinical impacts, helping patients struggling with a range of afflictions from addiction to depression and PTSD

• A Brief Practical Guide to PCR
• Managing a PCR Contamination Event in a Molecular Pathology Laboratory
• Next Generation Sequencing Informatic Architecture Considerations
• Nuclease Enrichment and qPCR Detection of Rare Nucleotide Variants
• MYD88 L265P Mutation Detection by ddPCR: Recommendations for Screening and Minimal Residual Disease Monitoring
• Capture Methylation-Sensitive Restriction Enzyme Sequencing (Capture MRE-Seq) for Methylation Analysis of Highly Degraded DNA
• LT-RPA: An Isothermal DNA Amplification Approach for Improved Microsatellite Genotyping and Microsatellite Instability Detection
• Liquid Biopsy for Advanced Cancer: An Amplicon Based Massively Parallel Sequencing Panel Approach to Precision Oncology
• Mate Pair Sequencing: Next Generation Sequencing for Structural Variant Detection
• Cell Subset-Specific Chimerism Testing by Short Tandem Repeats Analysis for Engraftment Monitoring After Hematopoietic Stem Cell Transplantation
• Immune Cell Lineage-Specific Chimerism Testing by Next-Generation Sequencing for Engraftment Monitoring After Allogeneic Hematopoietic Stem Cell Transplantation
• Rapid Whole Genome Sequencing for Diagnosis of Single Locus Genetic Diseases in Critically Ill Children
• EOSAL-CNV for Easy and Rapid Detection of CNVs by Fragment Analysis
• Rapid Cycle and Extreme Polymerase Chain Reaction
• CRISPR-Cas12-Based Diagnostic Applications in Infectious and Zoonotic Diseases
• SARS-CoV-2 Sequencing for Variant Surveillance
• Tuberculosis Diagnosis Using Isothermal Nucleic Acid Amplification in a Paper-and-Plastic Device
• Loop-Mediated Isothermal Amplification on Paper Microfluidic Chips for Highly Sensitive and Specific Zika Virus Detection Using Smartphone
• Ultrasensitive Reverse Transcriptase Loop-Mediated Isothermal Amplification (US-LAMP) Based Detection of Malaria Infection from Dried Blood Spots. .

This volume details applications, methods, and protocols on nucleic acid amplification. Chapters detail the management of organ and stem cell transplantation, constitutional genetics and genomics, epidemiology, public health, nucleic acid detection, methods for amplification and sequencing, nuclease-assisted mutant allele enrichment, isothermal, and high-throughput sequencing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Clinical Applications of Nucleic Acid Amplification is a valuable resource for both novice and expert scientists in this developing field.

• Everything it must be known about the relation of gluten to human health
• Raw materials. Traditional and non-conventional cereals, pseudo-cereals, oilseeds and legumes
• Non-cereals starch resources
• Use of additives in gluten-free formulations
• Fermented gluten-free baked goods
• Gluten free non-fermented bakery
• Gluten free edible films, coatings, and toppings
• Gluten free pasta production and formulation design
• Sensory analysis tools in developing gluten-free bakery and pasta products and their quality control
• Regulation and labelling. Methods of analysis for the determination of gluten in foods.

The ingestion of gluten in the human diet can lead to gastrointestinal disorders such as celiac disease, allergy to wheat and non-celiac gluten sensitivity. Currently the best treatment is the strict adherence to a diet without sources of prolamins and gliadins (wheat), secalin (rye) and hordein (barley). Several studies have revealed that a gluten-free diet may lead to nutrient deficiencies. Therefore, the formulation of gluten-free foods, particularly those related to cereals, is a major challenge. A great effort has been put into improved technological and nutritional aspects of gluten-free cereal products, as evidenced by the large amount of research published in journal articles. Thus far there has been no compilation of this up-to-date research which would lead to better implementation of healthy gluten-free products. Designing Gluten Free Bakery and Pasta Products provides a tool for designing gluten-free bakery and pasta products taking into account the most up-to-date advances and knowledge of gluten-related diseases, extensively covering both traditional and non-traditional gluten-free raw materials and bakery and pasta processes. This book will be particularly useful for food scientists and technologists developing gluten-free bakery and pasta products, plus physicians and nutritionists working with patients with gluten related diseases.

Non-communicable diseases, such as cardiovascular disease, cancer, diabetes, obesity, and hypertension, represent the cause of 60% of all deaths around the globe. With proper diet and natural dietary antioxidant supplements, these diseases can be prevented by up to 40% according to the British Nutrition Foundation. This book provides a comprehensive overview of the literature on the health benefits of natural dietary antioxidant supplements. It presents state-of-the-art research and information as well as the global regulations, labelling, and health claims of natural dietary antioxidant supplements. Written by expert authors, the wealth of research is arranged by disease type rather than by supplement type making it much more useful to the reader. Filling a gap in the literature, the book is aimed at researchers and professionals working in food chemistry, nutrition, and health benefits

• Drug Development in Psychiatry: The Long and Winding Road from Chance Discovery to Rational Development
• The History of Drug Development in Psychiatry: A Lesson in Serendipity
• The Evolving Role of Animal Models in the Discovery and Development of Novel Treatments for Psychiatric Disorders
• Discovery and Development of Monoamine Transporter Ligands
• Drug Development for New Psychiatric Drug Therapies
• Post-Approval Research in Drug Development: Priorities and Practices
• Discovery of new transmitter systems and hence new drug targets
• Reverse engineering drugs
• Back to the Future of Neuropsychopharmacology
• Targeted Treatments for Fragile X Syndrome
• The Difficult Path to the Discovery of Novel Treatments in Psychiatric Disorders Diseases
• Biomarkers in Psychiatric Drug Development: From Precision Medicine to Novel Therapeutics
• The role of fMRI in drug development: an update
• Monoamine Oxidase B (MAO-B): A Target for Rational Drug Development in Schizophrenia Using PET Imaging as an Example
• Genomics in Treatment Development
• Increased Inflammation and Treatment of Depression: from Resistance to Reuse, Repurposing and Redesign
• Experimental medicine approaches in early phase CNS drug development.

This new book reviews clinical trial methodology as it pertains to drug development in psychiatry. The authors will describe the process of drug development in psychiatry from discovery through marketing with the help of clinically relevant examples. The history of drug development in psychiatry is explored dating back to the era of serendipitous discovery and culminating in an era of new and highly focused targets. The book will delineate how drug development in psychiatry has changed and adapted with the discovery of drugs with novel mechanisms of action. Drug Development in Psychiatry elucidates how biomarkers, genetics, and advances in neuroscience and neuroimaging have influenced drug development approaches, which will ultimately change the practice of psychiatry. The book charts the early years of drug discovery by chance observation, reviews the developments of the past 50 years of refined targeting of CNS drugs without the discovery of mechanistically new drugs, and looks to the discovery of mechanistically new drugs, the examination of new targets, genetics, and biomarkers.

• Front Matter
• Introduction. Historical Perspective / ROBERTA S KING
• Factors Affecting Metabolism / ROBERTA S KING
• Biotransformations in Drug Metabolism / ROBERTA S KING
• A Comprehensive Picture of Biotransformation in Drug Discovery / JOE R CANNON, PRAKASH VACHASPATI, YANG YUAN
• In Vivo Drug Metabolite Kinetics / ZHENG YANG
• LC-MS / MS -Based Proteomics Methods for Quantifying Drug-Metabolizing Enzymes and Transporters / Logan S Smith, SUN MIN JUNG, JIAPENG LI, HAO-JIE ZHU
• Technologies for In vitro and In vivo Studies. Mass Spectrometry / THOMAS R SHARP
• Accelerating Metabolite Identification Mass Spectrometry Technology Drives Metabolite Identification Studies Forward / ALA F NASSAR
• Role of Structural Modifications of Drug Candidates to Enhance Metabolic Stability / ALA F Nassar
• Drug Design Strategies: Role of Structural Modifications of Drug Candidates to Improve PK Parameters of New Drugs / ALA F NASSAR
• Chemical Structural Alert and Reactive Metabolite Concept as Applied in Medicinal Chemistry to Minimize the Toxicity of Drug Candidates / ALA F NASSAR
• Studies of Reactive Metabolites using Genotoxicity Arrays and Enzyme/ DNA Biocolloids - 2021 / JAMES F RUSLING, ELI G HVASTKOVS
• Drug Interactions. Enzyme Inhibition / PAUL F HOLLENBERG
• Xenobiotic Receptor-Mediated Gene Regulation in Drug Metabolism and Disposition / HONGBING WANG, WEN XIE
• Characterization of Cytochrome P450 Mechanism Based Inhibition / DAN A ROCK, LARRY C WIENKERS
• An Introduction to Metabolic Reaction-Phenotyping / CARL DAVIS
• Epigenetic Regulation of Drug-Metabolizing Enzymes in Cancer / JIAQI WANG, XIAOLI ZHENG, SU ZENG
• Epigenetic Regulation of Drug Transporters in Cancer / YINGYING WANG, YING ZHOU, YU WANG, LUSHAN YU, SU ZENG
• Toxicity. The Role of Drug Metabolism in Toxicity / UMESH M HANUMEGOWDA, CARL DAVIS
• Allergic Reactions to Drugs / MARK P GRILLO
• Chemical Mechanisms in Toxicology / MARK P GRILLO
• Role of Bioactivation Reactions in Chemically Induced Nephrotoxicity / LAWRENCE H LASH
• Applications. Mapping the Heterogeneous Distribution of Cancer Drugs by Imaging Mass Spectrometry / PURVA S DAMALE, SHIBDAS BANERJEE
• Systemic Metabolomic Changes Associated with Chemotherapy: Role in Personalized Therapy / BHARGAB KALITA, GANESH K BARIK, TANISHA SHARMA, KHUSHMAN TAUNK, PRANEETA P BHAVSAR, MANAS K SANTRA, SRIKANTH RAPOLE
• Metabolic Reprogramming in Cancer / DEBASISH PRUSTY, Soumen Kanti Manna
• Case Study: Metabolism and Reactions of Alkylating Agents in Cancer Therapy / ALA F NASSAR, ADAM V WISNEWSKI, IVAN KING
• Rewiring of Drug Metabolism and Its Cross-talk with Metabolic Reprogramming in Cancer / SUBHABRATA MAJUMDER, Soumen Kanti Manna
• Principles of Drug Metabolism and Interactions in Cardio-Oncology / SHERRY-ANN BROWN, CRAIG BEAVERS, SAILAJA KAMARAJU, MEERA MOHAN, OLUBADEWA FATUNDE, GIFT ECHEFU, SVETLANA ZAHAROVA, BRIANNA WALLACE, CAROLYN OXENCIS
• Index

A comprehensive explanation of drug metabolism concepts and applications in drug development and cancer treatment In the newly revised second edition of Drug Metabolism Handbook: Concepts and Applications in Cancer Research, a distinguished team of researchers delivers an incisive and robust exploration of the drug metabolism system and a well-illustrated and detailed explanation of the latest tools and techniques used in the research, pharmacology, and medicine. The book discusses the creation of new molecular entities, drug development, troubleshooting, and other highly relevant concepts, guiding readers through new applications in pharmaceutical research, development, and assessment. The latest edition offers updated content on metabolism basics and the application of a variety of new techniques to cancer treatment, including mass spectrometry, imaging, metabolomics, and immunotherapy. It also offers in-depth case studies highlighting the role of metabolism in drug development. Readers will also benefit from: A thorough introduction to drug metabolism, including a historical perspective, factors affecting metabolism, and biotransformations in drug metabolism Comprehensive discussions of technologies for in vitro and in vivo studies, including mass spectrometry and accelerating metabolite identification with mass spectrometry In-depth explorations of drug interactions, including discussions of enzyme inhibition and the characterization of cytochrome P450 mechanism-based inhibition Fulsome treatments of drug toxicity, including the role of drug metabolism in toxicity, and allergic reactions to drugs Perfect for medicinal chemists, pharmaceutical scientists, and toxicologists, Drug Metabolism Handbook: Concepts and Applications in Cancer Research, Second Edition will also earn a place in the libraries of analytical chemists and drug discovery professionals.
(source: Nielsen Book Data)

• 1 Understanding pharmacotoxicology
• 2 Toxicology in drug research
• 3 Role of microRNAs in toxicology
• 4 Exosomes as mediators of chemical-induced toxicity
• 5 Drug-induced oxidative stress as a mechanism of toxicity
• 6 Role of “toxicant-induced loss of tolerance” in the emergence of disease
• 7 Types of cellular responses to chemical toxicants
• 8 Toxicant-induced injury and tissue repair
• 9 Computer-aided technologies in drug discovery and toxicity prediction
• 10 Predicting toxicity from chemical structure of a drug compound
• 11 Toxicokinetics and organ-specific toxicity
• 12 Drug-induced nephrotoxicity and its biomarkers
• 13 Mechanism of drug-induced neurotoxicity and its management
• 14 Thermal processing and food-related toxicants
• 15 Medication errors and approaches for its prevention
• 16 Understanding the bioaccumulation of pharmaceuticals and personal care products
• 17 Toxicity of dental materials and ways to screen their biosafety
• 18 Clinical detoxification of the body from chemical toxicants
• 19 Molecular mechanisms of the chemopreventive role of dietary phytochemicals
• 20 Toxicity labels
• 21 Toxic potential indicator
• 22 Concept of pharmacotherapy and managed care in clinical interventions
• 23 Understanding the connection between dietary supplementation and inadvertent doping
• 24 Cells and tissue-based models as a rational substitute in toxicity testing
• 25 Regulatory agencies for toxicological studies
• 26 Key challenges for toxicologists in the 21st century

• 1. Overview of natural products in nutraceutical industry
• 2. Curcuma longa
• 3. Zingiber Officinale
• 4. Boswellia Serrata
• 5. Piper Nigrum
• 6. Ocimum Sanctum
• 7. Moringa Oleifera
• 8. Galangal
• 9. Bacoppa Monnieri
• 10. Trigonella foenum-graecum
• 11. Withania Somnifera
• 12. Centella Asiatica
• 13. Rosmarinus Officinalis
• 14. Punica Granatum
• 15. Garcinia cambogia
• 16. Camellia sinensis
• 17. Ferula asafetida
• 18. Asparagus racemosus
• 19. Cinnamon/Cassia
• 20. Regulatory aspects of global nutraceuticals and functional foods for the utilization of herbs and spices - An insight
• 21. Current trends and technologies in nutraceutical industry
• 22. Future prospective of nutraceutical and functional foods with herbs and spices.
• (source: Nielsen Book Data)

Herbs, Spices and Their Roles in Nutraceuticals and Functional Foods gives an overview of the many pharmacological activities associated with herbs and spices, including detailed coverage on their mechanisms and formulations for the food industry. Chapters focus on key ingredients such as Curcuma longa, Piper Nigrum and Trigonella foenum-graecum, with contributors across the globe providing the latest research and advances for each. This is an essential read for scientists who want to understand the fundamental mechanisms behind the bioactive compounds within herbs and spices. The numerous phytochemicals present in plant extracts have multiple pharmacological activities so there is extensive research into new bioactive compounds. The pharmacological activities of herbs and spices have been thoroughly investigated, and it is crucial that the latest research is organized into a comprehensive resource.
(source: Nielsen Book Data)

• Targeted Protein Degradation - The Story So Far Cellular Principles of Targeted Protein Degradation E3 Ubiquitin Ligases as Molecular Machines and Platforms for Drug Development A Structural and Biophysical Perspective of Degrader Activity through Ternary Complex Formation Computational Modeling of PROTAC Ternary Complexes and Linker Design Molecular Glue Degraders: From Serendipity to Hunting and Design Targeted Protein Degradation as a Therapeutic Strategy in Neurodegenerative Diseases Insights and Future Perspectives of Covalent Protein Degraders Extending the Degradation Toolkit - mRNA targeting as Alternative Means to Affect Protein Levels The Future of Heterobifunctional Compounds: PROTACs and Beyond Destruction with a Purpose: Targeted Protein Degradation in Drug Discovery Taming the Beast: How to Optimize DMPK-PD Properties of Oral Degraders PROTAC? Protein Degraders: Bridging the Divide from Chemical Biology Tools to Clinical Candidates.
• (source: Nielsen Book Data)

• Introduction to protein homeostasis and the ubiquitin proteasome system E3 ligase complexes and their importance in protein degradation Molecular glues PROTACs Protein Degradation in Neuroscience Expanding the druggable proteome and identifying novel E3 ligases Controlling protein degradation by light Protein degradation from an industry perspective DMPK and protein degradation Degrading extracellular proteins Novel approaches in protein degradation: CHAMPS Novel approaches in protein degradation: Recruitment of novel UPS proteins Future outlook.
• (source: Nielsen Book Data)

Inducing Targeted Protein Degradation Enables drug developers in academia and industry to expand the range of accessible drug targets through induced protein degradation Since the breakthrough of the PROTAC technology in 2015, targeted protein degradation has revolutionized drug discovery, enabling pharma companies to develop completely novel therapeutics. Inducing Targeted Protein Degradation is a timely guide to navigating the complexities of the subject and understanding its practical application, with an eye on expanding the druggable space. In Inducing Targeted Protein Degradation, readers will find the most recent information on: Cellular mechanisms of targeted protein degradation and current approaches to utilize these mechanisms for drug discovery A comparison of different induced degradation approaches, including PROTAC, molecular glues, LYTACs and ATTECs as well as additional post translational modifications Drug development aspects such as DMPK optimization and criteria for the selection of clinical candidates A discussion of the potential of targeted degradation for expanding the druggable space Inducing Targeted Protein Degradation will serve as a practice-oriented reference on induced protein degradation for drug discovery professionals and for researchers employing chemical biology approaches.
(source: Nielsen Book Data)

• Chapter 1. Mushrooms as Promising Therapeutic Resources: Review and Future Perspectives
• Chapter 2. Medicinal Mushrooms for Respiratory Health
• Chapter 3. Therapeutic and Prophylactic Potential of Medicinal Mushrooms in COVID-19
• Chapter 4. Influences of Edible Mushrooms on Dynamic and Diversity of Gut Microbiota
• Chapter 5. Mushrooms From Traditional Remedies to the Modern Therapeutics
• Chapter 6. Biopharmaceutical Potential of Ophiocordyceps sinensis for Human Health
• Chapter 7. Anticancer Potential of Ganoderma lucidum and ts Relevant Modes of Action
• Chapter 8. Cognitive Enhancing Effects of Medicinal Mushrooms: A Potential Neuroprotective Implication in Dementias
• Chapter 9. Potential of Medicinal Mushrooms in Human Health and Welfare: An Overview
• Chapter 10. Mycotherapeutics Reduce Nephrotoxicity and Renal Diseases
• Chapter 11. Proteomic Research on the Therapeutic Properties of Medicinal Mushrooms
• Chapter 12. Cordyceps militaris (L.): Medicinal aspects in terms of ethnobotanical and pharmacological perspectives
• Chapter 13. Mycotherapeutics Affecting Dopaminergic Neurotransmission to Exert Neuroprotection
• Chapter 14. Biological Activities of Some Edible Mushrooms
• Chapter 15. Nephroprotective Effects of Four Ganoderma Species
• Chapter 16. Mechanisms Involved in EdibleMushrooms'Health Beneficial Effects
• Chapter 17. Mycotherapy (Medicinal Mushrooms) as a Potential Treatment for Epilepsy
• Chapter 18. Natural vs. Synthetic Psilocybin: The Same or Completely Different?
• Chapter 19. Preventative and Curative Properties of Reishi and Maitake Mushrooms in Cancer.

The book presents new and novel perceptions about ailments alleviating the effects of several mushroom species. Also, the book highlights the curative role of medicinal mushrooms on some peripheral and central diseases. Various chapters in the book (primarily reviews) have been dedicated to providing the therapeutic efficacy of mushrooms against respiratory illnesses, gut microbiota, COVID-19, dementia, epilepsy, mental ailments, cancers, cardiovascular, kidney-related diseases, and other common pathologies. Thus, medicinal mushrooms are current and future consumable healthcare products that usually exhibit nourishing properties and possess prophylactic and therapeutic values with minimal adverse effects and contraindications. The book focuses on Sustainable Development Goal (SDG 3) to promote healthy lives and well-being for all. Medical, pharmacy, nursing, and CAM (complementary and alternative medicine) students, practitioners, scholars, researchers, other healthcare professionals, and general readers are this books potential audience. The book can be adopted as a textbook for undergraduate and graduate courses so that the therapeutic potential of mushrooms can reach a wider audience. This book strives to create a new resource for the future use of medicinal mushrooms in various disorders.