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• Automatic Segmentation of Hippocampus for Longitudinal Infant Brain MR Image Sequence by Spatial-Temporal Hypergraph Learning
• Construction of Neonatal Diffusion Atlases via Spatio-Angular Consistency
• Selective Labeling: identifying representative sub-volumes for interactive segmentation
• Robust and Accurate Appearance Models based on Joint Dictionary Learning: Data from the Osteoarthritis Initiative
• Consistent multi-atlas hippocampus segmentation for longitudinal MR brain images with temporal sparse representation
• Sparse-Based Morphometry: Principle and Application to Alzheimer's Disease
• Multi-Atlas Based Segmentation of Brainstem Nuclei from MR Images by Deep Hyper-Graph Learning
• Patch-Based Discrete Registration of Clinical Brain Images
• Non-local MRI Library-based Super-resolution: Application to Hippocampus Subfield Segmentation
• Patch-based DTI grading: Application to Alzheimer's disease classification
• Hierarchical Multi-Atlas Segmentation using Label-Specific Embeddings, Target-Specific Templates and Patch Refinement
• HIST: HyperIntensity Segmentation Tool
• Supervoxel-Based Hierarchical Markov Random Field Framework for Multi-Atlas Segmentation
• CapAIBL: Automated reporting of cortical PET quantification without need of MRI on brain surface using a patch-based method
• High resolution hippocampus subfield segmentation using multispectral multi-atlas patch-based label fusion
• Identification of water and fat images in Dixon MRI using aggregated patch-based convolutional neural networks
• Estimating Lung Respiratory Motion Using Combined Global and Local Statistical Models.

This book constitutes the refereed proceedings of the Second International Workshop on Patch-Based Techniques in Medical Images, Patch-MI 2016, which was held in conjunction with MICCAI 2016, in Athens, Greece, in October 2016. The 17 regular papers presented in this volume were carefully reviewed and selected from 25 submissions. The main aim of the Patch-MI 2016 workshop is to promote methodological advances within the medical imaging field, with various applications in image segmentation, image denoising, image super-resolution, computer-aided diagnosis, image registration, abnormality detection, and image synthesis.

• Fundamental methods for image-based biophysical modeling and image synthesis
• Biophysical and data-driven models of disease progression or organ development
• Biophysical and data-driven models of organ motion and deformation
• Biophysical and data-driven models of image formation and acquisition
• Segmentation/registration across or within modalities to aid the learning of model parameters
• Cross modality (PET/MR, PET/CT, CT/MR, etc.) image synthesis
• Simulation and synthesis from large-scale image databases
• Automated techniques for quality assessment of simulations and synthetic images
• Image registration and segmentation
• Image denoising and information fusion
• Image reconstruction from sparse data or sparse views
• Real-time simulation of biophysical properties
• Simulation based approaches for medical imaging
• Synthesis and its applications in computational medical imaging.

This book constitutes the refereed proceedings of the First International Workshop on Simulation and Synthesis in Medical Imaging, held in conjunction with MICCAI 2016, in Athens, Greece, in October 2016. The 17 revised full papers presented together in this book were carefully reviewed and selected from 21 submissions. The contributions span the following broad categories: fundamental methods for image-based biophysical modeling and image synthesis; biophysical and data-driven models of disease progression or organ development; biophysical and data-driven models of organ motion and deformation; biophysical and data-driven models of image formation and acquisition; segmentation/registration across or within modalities to aid the learning of model parameters; cross modality (PET/MR, PET/CT, CT/MR, etc.) image synthesis; simulation and synthesis from large-scale image databases; automated techniques for quality assessment of simulations and synthetic images; as well as several applications of image synthesis and simulation in medical imaging such as image registration and segmentation; image denoising and information fusion; image reconstruction from sparse data or sparse views; and real-time simulation of biophysical properties. The papers were divided into two general topics named "simulation based approaches for medical imaging" and "synthesis and its applications in computational medical imaging."

• Part I Clinical Applications of Medical Imaging
• Part II Classification and Clustering- Part III Computer Aided Diagnosis (CAD) Tools and Case Studies
• Part-V Bio-inspiring Based Computer Aided Diagnosis Techniques.

This volume comprises of 21 selected chapters, including two overview chapters devoted to abdominal imaging in clinical applications supported computer aided diagnosis approaches as well as different techniques for solving the pectoral muscle extraction problem in the preprocessing part of the CAD systems for detecting breast cancer in its early stage using digital mammograms. The aim of this book is to stimulate further research in medical imaging applications based algorithmic and computer based approaches and utilize them in real-world clinical applications. The book is divided into four parts, Part-I: Clinical Applications of Medical Imaging, Part-II: Classification and clustering, Part-III: Computer Aided Diagnosis (CAD) Tools and Case Studies and Part-IV: Bio-inspiring based Computer Aided diagnosis techniques.

• Brain lesion image analysis
• Brain tumor image segmentation
• Ischemic stroke lesion image segmentation.

This book constitutes the thoroughly refereed post-workshop proceedings of the International Workshop on Brain Lesion (BrainLes), Brain Tumor Segmentation (BRATS) and Ischemic Stroke Lesion Segmentation (ISLES), held in Munich, Germany, on October 5, 2015, in conjunction with the International Conference on Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2015. The 25 papers presented in this volume were carefully reviewed and selected from 28 submissions. They are grouped around the following topics: brain lesion image analysis; brain tumor image segmentation; ischemic stroke lesion image segmentation.

• Introduction
• Image pre-processing
• Main Image processing
• Additional Image Processing and Measurement
• Impact of Image Acquisition and Selection of Algorithm Parameters on the Results
• Summary of Measured Features
• Conclusions.

This monograph focuses on the use of analysis and processing methods for images from the Corvis® ST tonometer. The presented analysis is associated with the quantitative, repeatable and fully automatic evaluation of the response of the eye, eyeball and cornea to an air-puff. All the described algorithms were practically implemented in MATLAB®. The monograph also describes and provides the full source code designed to perform the discussed calculations. As a result, this monograph is intended for scientists, graduate students and students of computer science and bioengineering as well as doctors wishing to expand their knowledge of modern diagnostic methods assisted by various image analysis and processing methods.

• A Multi-level Canonical Correlation Analysis Scheme for Standard-dose PET Image Estimation
• Image Super-Resolution by Supervised Adaption of Patchwise Self-Similarity from High-Resolution Image
• Automatic Hippocampus Labeling Using the Hierarchy of Sub-Region Random Forests
• Isointense Infant Brain Segmentation by Stacked Kernel Canonical Correlation Analysis
• Improving Accuracy of Automatic Hippocampus Segmentation in Routine MRI by Features Learned from Ultra-high Field MRI
• Dual-Layer l1-Graph Embedding for Semi-Supervised Image Labeling
• Automatic Liver Tumor Segmentation in Follow-up CT Studies Using Convolutional Neural Network
• Block-based Statistics for Robust Non-Parametric Morphometry
• Automatic Collimation Detection in Digital Radiographs with the Directed Hough Transform and Learning-based Edge Detection
• Efficient Lung Cancer Cell Detection with Deep Convolutional Neural Network
• An Effective Approach for Robust Lung Cancer Cell Detection
• Laplacian Shape Editing with Local Patch Based Force Field for Interactive Segmentation
• Hippocampus Segmentation through Distance Field Fusion
• Learning a Spatiotemporal Dictionary for Magnetic Resonance Fingerprinting with Compress Sensing
• Fast Regions-of-Interest Detection in Whole Slide Histopathology Images
• Reliability Guided Forward and Backward Patch-based Method for Multi-atlas Segmentation
• Correlating Tumour Histology and ex vivo MRI Using Dense Modality-Independent Patch-Based Descriptor
• Multi-Atlas Segmentation using Patch-Based Joint Label Fusion with Non-Negative Least Squares Regression
• A Spatially Constrained Deep Learning Framework for Detection of Epithelial Tumor Nuclei in Cancer Histology Images
• 3D MRI Denoising using Rough Set Theory and Kernel Embedding Method
• A Novel Cell Orientation Congruence Descriptor for Superpixel based Epithelium Segmentation in Endometrial Histology Images
• Patch-based Segmentation from MP2RAGE Images: Comparison to Conventional Techniques
• Multi-Atlas and Multi-Modal Hippocampus Segmentation for Infant MR Brain Images by Propagating Anatomical Labels on Hypergraph
• Prediction of Infant MRI Appearance and Anatomical Structure Evolution using Sparse Patch-based Metamorphosis Learning Framework
• Efficient Multi-Scale Patch-based Segmentation.

This book constitutes the thoroughly refereed post-workshop proceedings of the First International Workshop on Patch-based Techniques in Medical Images, Patch-MI 2015, which was held in conjunction with MICCAI 2015, in Munich, Germany, in October 2015. The 25 full papers presented in this volume were carefully reviewed and selected from 35 submissions. The topics covered are such as image segmentation of anatomical structures or lesions; image enhancement; computer-aided prognostic and diagnostic; multi-modality fusion; mono and multi modal image synthesis; image retrieval; dynamic, functional physiologic and anatomic imaging; super-pixel/voxel in medical image analysis; sparse dictionary learning and sparse coding; analysis of 2D, 2D+t, 3D, 3D+t, 4D, and 4D+t data.

• Probabilistic Graphical Models
• Colocalization Estimation Using Graphical Modeling and Variational Bayesian Expectation Maximization: Towards a Parameter-Free Approach
• Template-Based Multimodal Joint Generative Model of Brain Data
• Generative Method to Discover Genetically Driven Image Biomarkers
• MRI Reconstruction A Joint Acquisition-Estimation Framework for MR Phase Imaging
• A Compressed-Sensing Approach for Super-Resolution Reconstruction of Diffusion MRI
• Accelerated High Spatial Resolution Diffusion-Weighted Imaging
• Clustering
• Joint Spectral Decomposition for the Parcellation of the Human Cerebral Cortex Using Resting-State fMRI
• Joint Clustering and Component Analysis of Correspondenceless Point Sets: Application to Cardiac Statistical Modeling
• Statistical Methods
• Bootstrapped Permutation Test for Multiresponse Inference on Brain Behavior Associations
• Controlling False Discovery Rate in Signal Space for Transformation-Invariant Thresholding of Statistical Maps
• Longitudinal Analysis
• Group Testing for Longitudinal Data
• Spatio-Temporal Signatures to Predict Retinal Disease Recurrence
• Microstructure Imaging
• A Unifying Framework for Spatial and Temporal Diffusion in Diffusion MRI
• Ground Truth for Diffusion MRI in Cancer: A Model-Based Investigation of a Novel Tissue-Mimetic Material
• Shape Analysis
• Anisotropic Distributions on Manifolds: Template Estimation and Most Probable Paths
• A Riemannian Framework for Intrinsic Comparison of Closed Genus-Zero Shapes
• Multi-atlas Fusion Multi-atlas Segmentation as a Graph Labelling Problem: Application to Partially Annotated Atlas Data
• Keypoint Transfer Segmentation
• Fast Image Registration
• Finite-Dimensional Lie Algebras for Fast Diffeomorphic Image Registration
• Fast Optimal Transport Averaging of Neuroimaging Data
• Deformation Models
• Joint Morphometry of Fiber Tracts and Gray Matter Structures Using Double Diffeomorphisms
• A Robust Probabilistic Model for Motion Layer Separation in X-ray Fluoroscopy
• Poster Papers
• Weighted Hashing with Multiple Cues for Cell-Level Analysis of Histopathological Images
• Multiresolution Diffeomorphic Mapping for Cortical Surfaces
• A Comprehensive Computer-Aided Polyp Detection System for Colonoscopy Videos
• A Feature-Based Approach to Big Data Analysis of Medical Images
• Joint Segmentation and Registration Through the Duality of Congealing and Maximum Likelihood Estimate
• Self-Aligning Manifolds for Matching Disparate Medical Image Datasets
• Leveraging EAP-Sparsity for Compressed Sensing of MS-HARDI in (k, q)-Space
• Multi-stage Biomarker Models for Progression Estimation in Alzheimer's Disease
• Measuring Asymmetric Interactions in Resting State Brain Networks
• Shape Classification Using Wasserstein Distance for Brain Morphometry Analysis
• Temporal Trajectory and Progression Score Estimation from Voxelwise Longitudinal Imaging Measures: Application to Amyloid Imaging
• Predicting Semantic Descriptions from Medical Images with Convolutional Neural Networks
• Bodypart Recognition Using Multi-stage Deep Learning
• Multi-subject Manifold Alignment of Functional Network Structures via Joint Diagonalization
• Brain Transfer: Spectral Analysis of Cortical Surfaces and Functional Maps
• Finding a Path for Segmentation Through Sequential Learning
• Pancreatic Tumor Growth Prediction with Multiplicative Growth and Image-Derived Motion
• IMaGe: Iterative Multilevel Probabilistic Graphical Model for Detection and Segmentation of Multiple Sclerosis Lesions in Brain MRI
• Moving Frames for Heart Fiber Reconstruction
• Detail-Preserving PET Reconstruction with Sparse Image Representation and Anatomical Priors
• Automatic Detection of the Uterus and Fallopian Tube Junctions in Laparoscopic Images
• A Mixed-Effects Model with Time Reparametrization for Longitudinal Univariate Manifold-Valued Data
• Prediction of Longitudinal Development of Infant Cortical Surface Shape Using a 4D Current-Based Learning Framework
• Multi-scale Convolutional Neural Networks for Lung Nodule Classification
• Tractography-Driven Groupwise Multi-scale Parcellation of the Cortex
• Illumination Compensation and Normalization Using Low-Rank Decomposition of Multispectral Images in Dermatology
• Efficient Gaussian Process-Based Modelling and Prediction of Image Time Series
• A Simulation Framework for Quantitative Validation of Artefact Correction in Diffusion MRI
• Towards a Quantified Network Portrait of a Population
• Segmenting the Brain Surface from CT Images with Artifacts Using Dictionary Learning for Non-rigid MR-CT Registration
• AxTract: Microstructure-Driven Tractography Based on the Ensemble Average Propagator
• Sampling from Determinantal Point Processes for Scalable Manifold Learning
• Model-Based Estimation of Microscopic Anisotropy in Macroscopically Isotropic Substrates Using Diffusion MRI
• Multiple Orderings of Events in Disease Progression
• Construction of An Unbiased Spatio-Temporal Atlas of the Tongue During Speech
• Tree-Encoded Conditional Random Fields for Image Synthesis
• Simultaneous Longitudinal Registration with Group-Wise Similarity Prior
• Spatially Weighted Principal Component Regression for High-Dimensional Prediction
• Coupled Stable Overlapping Replicator Dynamics for Multimodal Brain Subnetwork Identification
• Joint 6D k-q Space Compressed Sensing for Accelerated High Angular Resolution Diffusion MRI
• Functional Nonlinear Mixed Effects Models for Longitudinal Image Data.

This book constitutes the proceedings of the 24th International Conference on Information Processing in Medical Imaging, IPMI 2015, held at the Sabhal Mor Ostaig College on the Isle of Skye, Scotland, UK, in June/July 2015. The 22 full papers and 41 poster papers presented in this volume were carefully reviewed and selected from 195 submissions. They were organized in topical sections named: probabilistic graphical models; MRI reconstruction; clustering; statistical methods; longitudinal analysis; microstructure imaging; shape analysis; multi-atlas fusion; fast image registration; deformation models; and the poster session.