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• SECTION 1: Molecular pathology of immune, inflammatory, and hemostatic disorders
• Immune responses at host barriers and their importance in systemic autoimmune diseases
• Statins and hemostasis: therapeutic potential based on clinical evidence
• Effects of adrenergic receptor stimulation on human hemostasis: A systematic review
• [alpha]1-adrenergic stimulation increases platelet adhesion to endothelial cells mediated by TRPC6
• Physical Activity, Burnout, and Engagement in Latin American Students of Higher Education during the COVID-19 Pandemic
• Small plastics, big inflammatory problems
• Impact of a community-based pelvic floor kinesic rehabilitation program on the quality of life of Chilean adult women with urinary incontinence
• SECTION 2: Molecular pathology of endocrine and muscular disorders
• Iodine intake based on a survey from a cohort of women at their third trimester of pregnancy from the Bosque County Chile
• Appraisal of the neuroprotective effect of dexmedetomidine: a meta-analysis
• Bile acids alter the autophagy and mitogenesis in skeletal muscle cells
• Upregulation of CCL5/RANTES gene expression in the diaphragm of mice with cholestatic liver disease
• Differential fibrotic response of muscle fibroblasts, myoblasts, and myotubes to cholic and deoxycholic acids
• BMAL1 regulates glucokinase expression through E-box elements in vitro
• SECTION 3: Molecular pathology of cancer: determinants and potential therapies
• Correlation between endoglin and malignant phenotype in human melanoma cells: analysis of hsa-mir-214 and hsa-mir-370 in cells and their extracellular vesicles
• Increase in Frequency of Myeloid-Derived Suppressor Cells in the Bone Marrow of Myeloproliferative Neoplasm: Potential Implications in Myelofibrosis
• The "Ins and Outs" of prostate specific membrane antigen (PSMA) as specific target in prostate cancer therapy
• Transforming Growth Factor-[beta]1 in Cancer Immunology: opportunities for immunotherapy.

The present work corresponds to a compilation of independent contributions in the fields of endocrinology, immunity, cancer, neurobiology, and myology. Revision of current advances as well as novel findings in the form of original articles are presented in a balanced fashion. The book has been divided into three sections in line with the main subject: Molecular pathology of immune, inflammatory, and hemostatic disorders; Molecular pathology of endocrine and muscular disorders; and Molecular pathology of cancer: determinants and potential therapies. In the first section, contributing authors take the reader through the molecular pathology of immune responses, inflammation, and hemostasis, by collating an update on systemic autoimmune diseases, the therapeutic potential of statins in hemostasis, the effects of adrenergic stimulation on coagulation, the emerging field of physical burnout due to the mobility restrictions in response to the 2020 SARS-CoV-2 pandemic imposed worldwide, and the success of community-oriented muscular kinesic rehabilitation. The second section presents engaging results from a survey of iodine intake through the diet of pregnant females, an appraisal of the neuroprotective effect of dexmedetomidine, novel evidence on muscle physiopathology, describing the upregulation of CCL5/RANTES during cholestatic liver disease, the fibrotic response emerging in response to cholic and deoxycholic acids, and the altering effects of bile acids in autophagy and mitogenesis. In the third section, a comprehensive revision of cancer literature is offered with an emphasis on melanoma, myeloid-derived suppressor cells, microRNA-based diagnostic approaches, and new avenues for cancer immunotherapy. Altogether, these individual contributions offer a comprehensive and up-to-date outlook of the current state in the field of molecular pathology. Chapter 14 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

• Genetic and Gentically-Susceptible Hypomelanoses.- Syndromes with Hypomelanosis.- Hypomelanoses Related to Inflammation and Immunological Reaction.- Hypochromic Hairs.- Miscellaneous Hypomelanoses and hypochromia.- Generalized and Localized Genetic Hyperpigmentation.- Hyperpigmentation with Cafe-au-lait Spots or Lentigines.- Syndromes with Hypermelanosis.- Linear and Blaschoid Hyperpigmentation.- Reticulated Hyperpigmentation.- Acquired Hypermelanoses.- Acquired Hyperchromia with Lichenoid Changes
• Acquired Hyperpigmentation with Keratotic Abnormalities.- Acquired Hyperpigmentation with Dermal Alterations.- Acquired and Congenital Dermal Hypermelanosis.- Miscellaneous Hyperpigmentation or Hypermelanosis.- Hyperpigmentation coexists with Hypopigmentation.- Disorders of Pigmentation of the Nails, Hair and Mucous Membrane.- Neoplasms with Dyschromatosis.- Non-melanotic Pigmentary Disorders with Abnormal Deposits. .
• (source: Nielsen Book Data)

This atlas is written to provide readers with the clinical and pathological presentation of the broad spectrum of pigmentary skin disorders (PSD). This book is divided into six parts and covers diseases of hypopigmentation, disorders of hyperpigmentation, hyperpigmentation coexisting with hypopigmentation, pigmentary disorders of the hair, nails, and mucous membranes, and neoplasms with dyschromatosis encountered in clinical practice. Written by experts with rich experience in the field, it will be an invaluable reference not only for dermatologists, cosmetologists, and geneticists but also for anyone interested in the exciting area of PSDs.
(source: Nielsen Book Data)

• Genetic and Gentically-Susceptible Hypomelanoses
• Syndromes with Hypomelanosis
• Hypomelanoses Related to Inflammation and Immunological Reaction
• Hypochromic Hairs
• Miscellaneous Hypomelanoses and hypochromia
• Generalized and Localized Genetic Hyperpigmentation
• Hyperpigmentation with Cafe-au-lait Spots or Lentigines
• Syndromes with Hypermelanosis
• Linear and Blaschoid Hyperpigmentation
• Reticulated Hyperpigmentation
• Acquired Hypermelanoses
• Acquired Hyperchromia with Lichenoid Changes
• Acquired Hyperpigmentation with Keratotic Abnormalities
• Acquired Hyperpigmentation with Dermal Alterations
• Acquired and Congenital Dermal Hypermelanosis
• Miscellaneous Hyperpigmentation or Hypermelanosis
• Hyperpigmentation coexists with Hypopigmentation
• Disorders of Pigmentation of the Nails, Hair and Mucous Membrane
• Neoplasms with Dyschromatosis
• Non-melanotic Pigmentary Disorders with Abnormal Deposits. .

This atlas is written to provide readers with the clinical and pathological presentation of the broad spectrum of pigmentary skin disorders (PSD). This book is divided into six parts and covers diseases of hypopigmentation, disorders of hyperpigmentation, hyperpigmentation coexisting with hypopigmentation, pigmentary disorders of the hair, nails, and mucous membranes, and neoplasms with dyschromatosis encountered in clinical practice. Written by experts with rich experience in the field, it will be an invaluable reference not only for dermatologists, cosmetologists, and geneticists but also for anyone interested in the exciting area of PSDs.

Economic Evaluation in Genomic and Precision Medicine provides an in-depth examination of essential concepts, protocols and applications of economic evaluation in genomic and precision medicine. Contributions from leading international medical geneticists and health economists compile new ways to effectively assess the costs and outcomes of different genomic care pathways, implement cost-effective medical interventions, and enhance the value of genomic and precision healthcare. Foundational chapters and discipline-specific case studies cover topics ranging from the economic analysis of genomic trial design, to health technology assessment of next-generation sequencing, ethical aspects, economic policy in genomic medicine, and pricing and reimbursement in clinical genomics.

• General knowledge about the nature of the COVID-19
• Epidemiological aspect of the COVID-19 pandemic
• Neurological manifestations of COVID-19
• COVID-19 headache as a secondary headache disorder
• COVID-19 headache is a real specific headache disorder. Potential mechanisms of COVID specific headache disorder
• Clinical pictures and diagnostic features of COVID-19 specific headache disorder
• Current management of COVID-19 infection
• Current management of COVID-19 headache.-Current changes of previous headache disorders in the pandemic era
• Effect of personal protective equipment on headache disorders
• Effect of COVID-19 vaccines on headache disorders
• Effect of ICU process on headache disorders
• Effects of vascular comorbidities on COVID-19 headache
• Effects of non-vascular comorbidities on COVID-19 headache
• Changing nature of headache practice in pandemic era
• Changing nature of headache education in pandemic era
• Changing nature of interventional pain management in pandemic era
• COVID-19 specific problems and solutions on childhood and adolescent headache practice
• COVID-19 specific problems and solutions on elderly headache practice
• COVID-19 specific problems and solutions on pregnancy and breastfeeding headache practice
• Genetic and epigenetic aspect of COVID-19 in the manner of headache practice
• Telemedicine for public headache awareness
• Telemedicine for headache education
• Telemedicine for headache research
• Artificial intelligence for future headache practice.

This book provides a physicians pathfinder for COVID specific headache disorders as well as general headache practice in a pandemic era. Practical solutions to headache management at every level are highlighted, along with the changing nature of previous headache disorders under lockdown conditions. Headache Disorders in Pandemic Conditions examines the specific nature of headache symptoms during COVID-19 infection, the secondary causes of COVID-specific headache disorders and practical issues of previous known headache disorders during a pandemic. The book also explores the effect of lockdown on headache management and changes in headache education, practice, risks and guidelines. Neurologists, headache specialists, general practitioners, medical students and residents will find this book to be a practical and clear guide to Covid-19 specific headache disorders in clinical practice.

• Section I - Basics of Regenerative Medicine 1) Introduction to Regenerative Medicine2) Prolotherapy3) Blood Productsa. Platelet Rich Plasmab. Platelet Poor Plasma with Alpha-2-Macroglobulinc. Orthokine4) Bone Marrow Aspirate/autologous stem cellsa. Techniquesb. Processingc. Applications5) Stromal Vascular Fraction (Adipose)a. Techniques (Mechanical vs. Enzymatic)b. Legality6) Fibrin7) Allografta. Guidelines for allograftb. Umbilical cordc. Wharton's Jellyd. Amniotic Tissue8) Autologous Expandeda. Bankingb. Expansion Rules & Regulationsc. Methods - Regenexx, etc
• Section II - Imaging, Guidance, & Planning9) Basics of Ultrasound10) In Plane vs. Out of Plane11) Probe Selection12) Technical Aspects13) Basics of Fluoroscopy14) Fluoro Safety15) Pre-Treatment Planninga. Imaging (i.e. MRI)b. Discographyc. Pre-procedure planning for u/s guided injections16) Local Anesthetic & NSAID's
• Section III - Treatment Paradigms- 17) Tendon - Allograft, Autologous, Concepts, Studies and Recommendations18) Ligament - Allograft, Autologous, Concepts, Studies, and Recommendations19) Joint - Allograft, Autologous, Concepts, Studies, and Recommendationsa. Kneeb. Hipc. Shoulderd. Elbowe. Anklef. Hand/wrist 20) Axial Skeleton - Allograft, Autologous, Concepts, Studies and Recommendationsa. Intervertebral Discsb. Facetsc. SIJ21) Wound healing a. Allograft, Autologous22) Aesthetics a. Allograft, Autologousb. Hair regrowthc. Facials.
• (source: Nielsen Book Data)

This book explores the rapidly growing subspecialty of regenerative medicine in pain management. It provides concise guidelines and instruction for healthcare providers interested in implementing this novel therapy. The book contains three sections and begins with a thorough introduction to the field. Additionally, section one examines various therapies such as stem cell collection, allograft therapies, and bone marrow aspirations. Section two then delves into the medical diagnosis and procedural guidance methods, including ultrasound imaging, discography, local anesthetics, and anticoagulation medications. Following this, section three concludes the book with numerous discussions on standardized treatment paradigms. A unique, first-of-its-kind book, Regenerative Medicine seeks to inspire medical practitioners to integrate this subspecialty into pain management therapies and treatments.
(source: Nielsen Book Data)

• Part I. Basics of Regenerative Medicine
• Chapter 1. Introduction to Regenerative Medicine
• Chapter 2. Prolotherapy
• Chapter 3. Blood Products
• Chapter 4. Bone Marrow Aspirate and the Use of Autologous Cells and Cellular Products in Regenerative Medicine
• Chapter 5. Adipose-Derived Stromal Stem Cells
• Chapter 6. Intra-annular Fibrin DiscseelProcedure to Diagnose and Treat Disc Pathology.-Chapter 7. Allograft Therapies in Regenerative Medicine
• Chapter 8. Adult Mesenchymal Stem Cell Collection and Banking
• Chapter 9. Exosomes
• Chapter 10. Exosomes in Stroke and Trauma: Current Concepts for Clinicians.-Part II. Imaging, Guidance, and Planning
• Chapter 11. Basics of Ultrasound
• Chapter 12. Ultrasound Guided Interventions: In-Plane and Out-of-Plane
• Chapter 13. Probe Selection
• Chapter 14. Diagnostic Musculoskeletal Ultrasound: Recognizing Pathology
• Chapter 15. Fluoroscopic Safety
• Chapter 16. Pre-procedural Imaging
• Chapter 17. Discography
• Chapter 18. Procedure Planning for Ultrasound Guided Injections
• Chapter 19. Effects of Local Anesthetics and Contrast Agents on Regenerative Medicine Procedures
• Chapter 20. Medicolegal Aspects of Regenerative Medicine.-Chapter 21. Anti-Platelet and Anticoagulation Medications
• Chapter 22. Patient Factors Affecting Regenerative Medicine Outcomes.-Part III. Treatment Paradigms Orthobiologics and Additional Utilities
• Chapter 23. Tendinopathy
• Chapter 24. Bone Marrow Derived Stem Cells and their Application in Pain Medicine
• Chapter 25. The Use of Platelet-Rich Plasma and Mesenchymal Stem Cells in the Lumbar and Lumbosacral Spine: Concepts, Literature Review and Recommendations
• Chapter 26. Adipose Derived Regenerative Cellular Therapy of Chronic Wounds
• Chapter 27. Aesthetic Surgery Applications for Adipose-Derived Stem Cells.

This book explores the rapidly growing subspecialty of regenerative medicine in pain management. It provides concise guidelines and instruction for healthcare providers interested in implementing this novel therapy. The book contains three sections and begins with a thorough introduction to the field. Additionally, section one examines various therapies such as stem cell collection, allograft therapies, and bone marrow aspirations. Section two then delves into the medical diagnosis and procedural guidance methods, including ultrasound imaging, discography, local anesthetics, and anticoagulation medications. Following this, section three concludes the book with numerous discussions on standardized treatment paradigms. A unique, first-of-its-kind book, Regenerative Medicine seeks to inspire medical practitioners to integrate this subspecialty into pain management therapies and treatments.

• Preliminary remarks
• Test: How much is your everyday life determined by pain?- Part I: What you should know about pain
• Part II:Exercises and techniques for coping with pain
• Part III: Changes in unfavourable behaviour
• Service section: Copy template for a pain protocol
• Contact details of various pain relief societies
• Literature. Index.

What you can do yourself against your pain This book shows concrete techniques and exercises of psychological pain management, with which it is possible to reduce pain permanently. It is aimed at all pain patients who want to actively manage pain and at all therapists and doctors who want to support their patients in this. The more than 30 successful techniques and exercises can be used alone at home without a doctor or therapist. Each exercise is explained step-by-step and simply, is scientifically recognized, has no side effects, and is effective regardless of the cause or location of the pain. The 4th edition is completely updated. From the contents Test: How much is your everyday life determined by pain? What you should know about pain Techniques and exercises to cope with pain, including thought-stopping techniques, redirecting attention, rest and relaxation techniques, progressive muscle relaxation according to Jakobson, special breathing techniques, fantasy journeys, self-hypnosis, biofeedback. Changes in unfavourable behaviour Service part with copy template for a pain protocol and addresses of self-help societies The author Dr. phil. Jutta Richter is a psychologist and physiotherapist. She has been working with patients with chronic pain in hospital and in her own practice for over 20 years. She gives advanced training, courses and lectures on the topic of "pain, stress management and communication.

• 1.Introductory remarks and background
• Anatomy and physiology of the vestibular and the ocular motor system
• How to take the patient history
• How to examine the vestibular and the ocular motor system
• Laboratory examinations
• Imaging
• General principles of therapy,
• vestibular exercises and rehabilitation, pharmacotherapy, surgery, and psychological and behavioural treatment
• 2. Peripheral vestibular disorders
• Introduction and classification
• Bilateral vestibulopathy
• Acute unilateral vestibulopathy
• Benign paroxysmal positional vertigo
• Menires disease
• Vestibular paroxysmia
• Superior canal dehiscence syndrome
• Perilymph fistula
• Current therapy
• 3. Central vestibular disorders
• Acute peripheral vs acute central vestibular syndromes
• Classification of central vestibular disorders
• Cerebellar dizziness
• Vestibular migraine
• vestibular migraine, and current clinical trials
• Central types of nystagmus
• Cerebellar dizziness
• Cerebellar ataxias.
• 4. Functional dizziness
• Persistent postural perceptual dizziness
• Phobic postural dizziness
• Visual dizziness
• 5. Various Vertigo Syndromes
• Traumatic vertigo
• Vertigo in childhood
• Cervicogenic vertigo
• Drug-induced dizziness
• Mal de dbarquement syndrome
• Motion sickness
• Height vertigo and acrophobia.

The third edition of this successful book has been fully revised, expanded and updated to reflect the recent advances in vertigo and dizziness, especially with regard to current classifications and clinical trials. The book starts by covering the fundamentals of anatomy and physiology of the vestibular and the ocular motor systems. It provides guidance on how to take the patient history, laboratory and imaging analysis and principles of therapy exploring different therapeutic strategies. It then goes on to cover in detail the diagnosis and current treatment of peripheral, central and functional vestibular disorders as well as miscellaneous rare vestibular syndromes. Using a uniform chapter style to address the various diseases and adopting a reader-friendly educational format, this is an indispensable guide for clinicians who treat patients with vertigo, dizziness and balance disorders. Hundreds of patient videos are included for the diseases demonstrating typical patient histories and clinical findings. Chapters have also been expanded to discuss the current classification and therapies as well as new and ongoing clinical trials with ample new figures. Written by three top experts in the field, this book is aimed at a broad range of medical specialists, namely neurologists, ENT specialists, neuro-otologists, ophthalmologists, physiotherapists, general practitioners as well as residents and students.

• Section 1: Understanding Chronic and neuropathic pain
• Classification of Chronic pain
• The Challenges in Dealing with Chronic and Neuropathic Pains
• Section 2: Pathophysiology
• The Pathophysiology of Chronic Pains
• The Pathophysiology of Neuropathic Pain
• Section 3: Age and Pain
• Pain in Children and Young Adults
• Pain in older adults
• Section 4: Pain processing medical problems
• Cancer and Pain
• Degenerative Diseases and Pain
• Complex Regional Pain Syndromes
• Neuropathic Pain Syndromes
• Fibromyalgia as a Neuropathic Pain Disorder
• Section 5: Clinical Matters
• Clinical Assessment
• Diagnostic testing of neuropathic pain
• Outcome Measures for chronic Pain
• Section 6: Management of chronic and neuropathic pains
• Non-Pharmacologic Modalities to Chronic and Neuropathic Pains
• Pharmacologic Approaches to Chronic and Neuropathic Pains
• Section 7: Interventional Therapy
• Interventional Procedures for Chronic and Neuropathic Pains
• Regenerative Interventions in Chronic and Neuropathic Pains.

This book is an in depth guide to chronic and neuropathic pain. The issue of chronic and neuropathic pain is very prevalent, yet only a fraction of the symptoms and root causes, as well as potential treatment plans, are properly understood. Additionally, less than half of cases are accurately identified and properly treated. The existing drugs, although classified as very strong and powerful, cannot provide lasting relief to chronic and neuropathic pain. Thus, with all the unique features of this condition, this book presents a systematic way of diagnosing and approaching this condition so every practitioner can appropriately treat their patients. In addition to introducing key concepts, like classification of chronic pain and the challenges patients and practitioners face when dealing with and treating chronic and neuropathic pain, this book will also cover different syndromes that can lead to neuropathic pains. It also discusses how to monitor progress by using outcome measures, the presence of chronic and neuropathic pain in children and young adults, and the pathophysiology of neuropathic pain as it relates to the release of pro-inflammatory cytokines. Interestingly, the latter is not presently addressed except with the usual pain drugs for general painthis book aims to revolutionize the approach to chronic and neuropathic pain by exploring it separately from the clinical approach to general pain. It is interesting to note that these cytokines require a specific mode of action if we want to neutralize them in our system, and this concept will be discussed in the regenerative intervention sections. Since it is so necessary to address the many factors to chronic and neuropathic pain as laid out in the proposed table of contents, it is also critical include as varied authors as possible to address this condition from all areas being covered. The team assembled to author the chapters included in this text come from diverse backgrounds of practice and clinical and research interests, from physical medicine and rehabilitation to anesthesiology to radiology and interventional pain medicine. This is an ideal guide for all clinicians caring for patients with chronic and neuropathic pain.

• Section 1: Understanding Chronic and neuropathic pain
• Introduction ( the editor)
• Classification of Chronic pain
• The Challenges in Dealing with Chronic and
• Neuropathic Pains (Filipinas Ganchoon, MD)
• Section 2: Pathophysiology
• The Pathophysiology of Chronic Pains (Abdallah El-Sayed Allam, MD - dr_3llam2007@hotmail.com))
• The Pathophysiology of Neuropathic Pain ( Dr Colin Chong)
• Section 3: Age and Pain
• Pain in Children and Young Adults (Dessy Emril, MD)
• Pain in older adults ((Wesley chih chun chen)
• Section 4: Pain processing medical problems
• Cancer and Pain (TCT
• Novy)
• Degenerative Diseases and Pain (Ernie Cruz, MD, et al, escruz7883@gmail.com)
• Complex Regional Pain Syndromes (Ravi Kalathur, MD)
• Neuropathic Pain Syndromes (e.g. Diabetic neuropathic pain, HIV
• related pain syndromes, Acute herpes zoster, postmastectomy pain syndrome,
• Amputation (phantom pain), post thoracotomy pain, spinal cord injuries,
• traumatic brain injury, MS, trigeminal neuralgia, thoracic outlet
• syndrome, piriformis syndrome - George Chen, MD
• .Fibromyalgia as a Neuropathic Pain Disorder (Yasser El Miedany)
• Section 5: Clinical Matters
• Clinical Assessment
• 12 Diagnostic testing of neuropathic pain (Dr. Eman Tawfik)
• 13.Outcome Measures for chronic Pain (Natalie Winter) email: natalie.winter@med.uni-tuebingen.de)
• Section 6: Management of chronic and neuropathic pains
• 14. Non-Pharmacologic Modalities to Chronic and Neuropathic Pains (Rey Matias, MD, drreymatias@gmail.com)
• 15. Pharmacologic Approaches to Chronic and Neuropathic Pains (David Cassius, MD, dr.cassius@gmail.com)
• Section 7: Interventional Therapy:
• 16. Interventional Procedures for Chronic and Neuropathic Pains (Agnes Stogicza, MD, psi@painschoolinternational.com-- stogicza@gmail.com)
• 17. Regenerative Interventions in Chronic and Neuropathic Pains (Jeimylo C de Castro, MD).
• (source: Nielsen Book Data)

This book is an in depth guide to chronic and neuropathic pain. The issue of chronic and neuropathic pain is very prevalent, yet only a fraction of the symptoms and root causes, as well as potential treatment plans, are properly understood. Additionally, less than half of cases are accurately identified and properly treated. The existing drugs, although classified as very strong and powerful, cannot provide lasting relief to chronic and neuropathic pain. Thus, with all the unique features of this condition, this book presents a systematic way of diagnosing and approaching this condition so every practitioner can appropriately treat their patients. In addition to introducing key concepts, like classification of chronic pain and the challenges patients and practitioners face when dealing with and treating chronic and neuropathic pain, this book also covers different syndromes that can lead to neuropathic pains. It discusses how to monitor progress by using outcome measures, the presence of chronic and neuropathic pain in children and young adults, and the pathophysiology of neuropathic pain as it relates to the release of pro-inflammatory cytokines. Interestingly, the latter is not presently addressed except with the usual pain drugs for general pain-this book aims to revolutionize the approach to chronic and neuropathic pain by exploring it separately from the clinical approach to general pain. It is interesting to note that these cytokines require a specific mode of action if we want to neutralize them in our system, and this concept will be discussed in the regenerative intervention sections. Since it is so necessary to address the many factors to chronic and neuropathic pain as laid out in the proposed table of contents, it is also critical include as varied authors as possible to address this condition from all areas being covered. The team assembled to author the chapters included in this text come from diverse backgrounds of practice and clinical and research interests, from physical medicine and rehabilitation to anesthesiology to radiology and interventional pain medicine. This is an ideal guide for all clinicians caring for patients with chronic and neuropathic pain.
(source: Nielsen Book Data)

• Introduction: Integration of computational pathology and AI application into histopathology workflow / Ralf Huss
• Standardized tissue sampling for automated analysis and global trial success / Eike von Leitner, Philipp Layer, Hartmut Juhl
• Light-sheet microscopy as a novel tool for virtual histology / Rene Hägerling, Fabian Mohr
• Stain quality management & biomarker analysis / Søren Nilson
• Measuring Ki-67 In breast cancer : past, present, and future / Andrew Dodson
• Multiplex : from acquisition to analysis / Regan Baird and David Mason
• An introduction to deep learning in pathology / Jeremias Krause, Heike I. Grabsch, Jakob Nikolas Kather
• AI-driven precision pathology : challenges and innovations in tissue biomarker analysis for diagnosis / Dirk Vossen, Jeppe Thagaard, Fabian Schneider, Rasmus Norré Sørensen, Johan Dorén, Esther Abels, Amanda Lowe, Mogens Vyberg, Michel Grunkin
• Tissue cartography for colorectal cancer / Volker Bruns, Michaela Benz, and Carol Geppert
• Graph representation learning & explainability in breast cancer pathology : bridging the gap between AI and pathology practice / Pushpak Pati, Guillaume Jaume, Antonio Foncubierta-Rodriguez, Florinda Feroce, Giosue Scognamiglio, Anna Maria Anniciello, Nadia Brancati, Maria Frucci, Daniel Riccio, Jean-Philippe Thiran, Orcun Goksel, Maria Gabrani
• AI-driven design of disease sensors : theoretical foundations / Simone Bianco, Sara Capponi, and Shangying Wang

Artificial Intelligence Applications in Human Pathology deals with the latest topics in biomedical research and clinical cancer diagnostics. With chapters provided by true international experts in the field, this book gives real examples of the implementation of AI and machine learning in human pathology.Advances in machine learning and AI in general have propelled computational and general pathology research. Today, computer systems approach the diagnostic levels achieved by humans for certain well-defined tasks in pathology. At the same time, pathologists are faced with an increased workload both quantitatively (numbers of cases) and qualitatively (the amount of work per case, with increasing treatment options and the type of data delivered by pathologists also expected to become more fine-grained). AI will support and leverage mathematical tools and implement data-driven methods as a center for data interpretation in modern tissue diagnosis and pathology. Digital or computational pathology will also foster the training of future computational pathologists, those with both pathology and non-pathology backgrounds, who will eventually decide that AI-based pathology will serve as an indispensable hub for data-related research in a global health care system.Some of the specific topics explored within include an introduction to DL as applied to Pathology, Standardized Tissue Sampling for Automated Analysis, integrating Computational Pathology into Histopathology workflows. Readers will also find examples of specific techniques applied to specific diseases that will aid their research and treatments including but not limited to; Tissue Cartography for Colorectal Cancer, Ki-67 Measurements in Breast Cancer, and Light-Sheet Microscopy as applied to Virtual Histology.The key role for pathologists in tissue diagnostics will prevail and even expand through interdisciplinary work and the intuitive use of an advanced and interoperating (AI-supported) pathology workflow delivering novel and complex features that will serve the understanding of individual diseases and of course the patient.
(source: Nielsen Book Data)

• Introduction and Nomenclature
• Section I: The Basic Pain Pathway and the Molecular Mechanisms That Determine the Intensity and Duration of Pain 1. Pain as a Property of the Nervous System 2. Organization of the Human Nervous System: From Nerves to Neurons 3. Pain: Perception and Attribution 4. The Molecular Neurobiology of Pain 5. Adaptation 6. Molecular Signals for Persistent Pain 7. The Sources of Pain
• Section II: The Modulation of Pain by Circuits in the Brain 8. The External Modulation of Pain: Descending Systems 9. Alleviating Pain: The Pharmacological Approach 10. The Neuromatrix 11. The Brain and Pain 12. The Mind Regulating the Mind 13. Pain Management: Present and Future Acknowledgments Notes Index.
• (source: Nielsen Book Data)

Pain is an inevitable part of existence, but severe debilitating or chronic pain is a pathological condition that diminishes the quality of life. The Brain and Pain explores the present and future of pain management, providing a comprehensive understanding based on the latest discoveries from many branches of neuroscience. Richard Ambron-the former director of a neuroscience lab that conducted leading research in this field-explains the science of how and why we feel pain. He describes how the nervous system and brain process information that leads to the experience of pain, detailing the cellular and molecular functions that are responsible for the initial perceptions of an injury. He discusses how pharmacological agents such as opiates affect the duration and intensity of pain. Ambron examines new evidence showing that discrete circuits in the brain modulate the experience of pain in response to a placebo, fear, anxiety, belief, or other circumstances, as well as how pain can be relieved by activating these circuits using mindfulness training and other nonpharmacological treatments. The book also evaluates the prospects of procedures such as deep brain stimulation and optogenetics. Current and thorough, The Brain and Pain will be invaluable for a range of people seeking to understand their options for treatment as well as students in neuroscience and medicine.
(source: Nielsen Book Data)

• Introduction and Nomenclature
• Section I: The Basic Pain Pathway and the Molecular Mechanisms That Determine the Intensity and Duration of Pain 1. Pain as a Property of the Nervous System 2. Organization of the Human Nervous System: From Nerves to Neurons 3. Pain: Perception and Attribution 4. The Molecular Neurobiology of Pain 5. Adaptation 6. Molecular Signals for Persistent Pain 7. The Sources of Pain
• Section II: The Modulation of Pain by Circuits in the Brain 8. The External Modulation of Pain: Descending Systems 9. Alleviating Pain: The Pharmacological Approach 10. The Neuromatrix 11. The Brain and Pain 12. The Mind Regulating the Mind 13. Pain Management: Present and Future Acknowledgments Notes Index.
• (source: Nielsen Book Data)

Pain is an inevitable part of existence, but severe debilitating or chronic pain is a pathological condition that diminishes the quality of life. The Brain and Pain explores the present and future of pain management, providing a comprehensive understanding based on the latest discoveries from many branches of neuroscience. Richard Ambron-the former director of a neuroscience lab that conducted leading research in this field-explains the science of how and why we feel pain. He describes how the nervous system and brain process information that leads to the experience of pain, detailing the cellular and molecular functions that are responsible for the initial perceptions of an injury. He discusses how pharmacological agents such as opiates affect the duration and intensity of pain. Ambron examines new evidence showing that discrete circuits in the brain modulate the experience of pain in response to a placebo, fear, anxiety, belief, or other circumstances, as well as how pain can be relieved by activating these circuits using mindfulness training and other nonpharmacological treatments. The book also evaluates the prospects of procedures such as deep brain stimulation and optogenetics. Current and thorough, The Brain and Pain will be invaluable for a range of people seeking to understand their options for treatment as well as students in neuroscience and medicine.
(source: Nielsen Book Data)

• Part I. The Political Bioethics of Regulating Genetic Engineering: 1. Regulation Guided by Proceduralism
• 2. Regulation Guided by Less-than-Universal Standards
• 3. Regulation Guided by Human Nature as Construction Not Essence
• 4. Regulation Guided by Human Dignity as Decisional Autonomy Not Essence
• Part II. The Political Dimensions of Engineering Intelligence: 5. Threshold Capacities for Political Participation
• 6. Political Capacity of Human Intelligence and the Challenge of AI
• 7. Political Ambiguity of Personalized Education Informed by the Pupil's Genome
• Part III. Inequality as Unintended Consequence Locally and as a Planetary Phenomenon: 8. A Human Right to Freedom from Genetic Disability
• 9. Deploying Epigenetics to Identify Responsibility for Health Inequalities
• 10. Genetic Engineering as a Technology of the Anthropocene
• Coda: Bioethics as Political Theory.
• (source: Nielsen Book Data)

Human genetic enhancement, examined from the standpoint of the new field of political bioethics, displaces the age-old question of truth: What is human nature? This book displaces that question with another: What kind of human nature should humans want to create for themselves? To answer that question, this book answers two others: What constraints should limit the applications of rapidly developing biotechnologies? What could possibly form the basis for corresponding public policy in a democratic society? Benjamin Gregg focuses on the distinctly political dimensions of human nature, where politics refers to competition among competing values on which to base public policy, legislation, and political culture. This book offers citizens of democratic communities a broad perspective on how they together might best approach urgent questions of how to deal with the socially and morally challenging potential for human genetic engineering.
(source: Nielsen Book Data)

• 1. Cyclic vomiting syndrome health expereinces among patients and their caregivers
• 2. Central nervous system pathways of nausea and vomiting
• 3. Clinical features of cyclic vomiting syndrome
• 4. Cyclic vomiting syndrome subtypes - do they provide insight into cyclic vomiting syndrome pathogenesis
• 5. Clinical and pathophysiological relationship between migraines and cyclic vomiting syndrome
• 6. Psychosocial contributors to cyclic vomiting syndrome
• 7. Treatment of acute cyclic vomiting syndrome attacks
• 8. Prevention of recurrent cyclic vomiting syndrome episodes
• 9. Clinical features of cannabinoid hyperemesis syndrome
• 10. How common is cannabinoid hyperemesis syndrome and why is it so hard to diagnose?
• 11. Proposed mechanisms of cannabinoid hyperemesis syndrome - how can cannabinoid pathways both relieve and cause vomiting?
• 12. The curious association of hot-water bathing with cyclic vomiting and cannabinoid hyperemesis syndromes
• 13. Management of cannabinoid hyperemesis syndrome - is it more than just avoiding cannabis use?
• 14. Role of emergency department in cyclic vomiting syndrome and cannabinoid hyperemesis syndrome care
• 15. What can be accomplished to advance the field?
• (source: Nielsen Book Data)

Cyclic Vomiting Syndrome and Cannabinoid Hyperemesis comprehensively reviews the clinical features and pathophysiology of cyclic vomiting syndrome (CVS) and cannabinoid hyperemesis syndrome (CHS). This book differentiates the clinical presentation of CVS and CHS from other vomiting syndromes and provides the information necessary to diagnose and effectively treat these disorders. Compiled by expert CVS/CHS clinicians and written by physicians and researchers from several disciplines, this reference provides the most updated, evidence-based approaches, and summarizes the latest research on CVS/CHS. Important topics such as the neural systems that drive nausea and vomiting, clinical features of CVS/CHS including its subtypes, insights into pathogenesis, as well as the curious association of hot-water bathing associated with both of these disorders are all explored. This is a must-have reference for residents and fellows in training, as well as busy clinicians who care for patients with CVS and CHS across multiple care settings including ambulatory clinics, the emergency department, hospitals, and substance use/abuse treatment centers. It is also a useful reference for investigators with an interest in these vomiting disorders.
(source: Nielsen Book Data)