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"From the latest vaccination evidence, recommendations, and protocols . . . to new vaccine development and the use of vaccines in reducing disease, Plotkin’s Vaccines, 8th Edition, covers every aspect of vaccination. Now completely revised and updated from cover to cover, this award-winning text continues to provide reliable information from global authorities, offering a complete understanding of each disease, as well as the latest knowledge of both existing vaccines and those currently in research and development. Described by Bill Gates as "an indispensable guide to the enhancement of the well-being of our world," Plotkin’s Vaccines is a must-have reference for current, authoritative information in this fast-moving field." -- Provided by publisher.

Advanced Microbial Techniques in Agriculture, Environment, and Health Management provides current perspectives on the fields of agriculture, the environment and health. This important reference presents recent advancements in applied microbial technology, compiling it in a comprehensive manner and transferring applied microbial technology from laboratory conditions to field level. In 20 chapters, the book focuses on microbial interventions for all-inclusive, cost-effective environmental management tactics while also linking the cumulative microbial services involved in the up-gradation of agriculture, environment and health. In addition, the book offers detailed information on emerging environmental issues and proposes ways of controlling their consequences using different approaches to treatment.

• Chapter 1. Artificial Intelligence for Global Healthcare
• Chapter 2. Artificial Intelligence for Epidemiology COVID-19: Quick Assessment
• Chapter 3. Artificial Intelligence in rural health in developing countries
• Chapter 4. THE ROLE OF ARTIFICIAL INTELLIGENCE TO TRACK COVID-19 DISEASE
• Chapter 5. Artificial Intelligence Techniques based on K-Means two way Clustering and Greedy Triclustering approach for 3D Gene Expression Data (GED)
• Chapter 6. Detection of COVID-19 cases from X-Ray and CT Images using Transfer Learning & Deep Convolution Neural Networks
• Chapter 7. Computer Vision: Augmented Reality (AR), Virtual Reality (VR), Telehealth and Digital Radiology
• Chapter 8. STROKE DISEASE PREDICTION MODEL USING ANOVA WITH CLASSIFICATION ALGORITHMS
• Chapter 9. A CONCISE REVIEW ON DEVELOPMENTAL AND EVALUATION METHODS OF ARTIFICIAL INTELLIGENCE ON COVID 19 DETECTION
• Chapter 10. Artificial Intelligence based Healthcare Industry 4.0 for Disease Detection using Machine Learning Techniques
• Chapter 11. Deep Autoencoder Neural Networks for Heart Sound Classification.

This book comprehensively reviews the potential of Artificial Intelligence (AI) in biomedical research and healthcare, with a major emphasis on virology. The initial chapter presents the applications of machine learning methods for structured data, such as the classical support vector machine and neural network, modern deep learning, and natural language processing for unstructured data in biomedical research and healthcare. The subsequent chapters explore the applications of AI in tackling COVID-19, analysis of the pandemic, viral infection, disease spread, and control. The book further identifies the potential applications of machine learning in the field of virology with a focus on the key aspects of infection: diagnosis, transmission, response to treatment, and resistance. The book also discusses progress and challenges in developing viral vaccines and examines the application of viruses in translational research and human healthcare. Furthermore, the book covers the applications of artificial intelligence-mediated diagnosis and the development of drugs to treat the disease. Towards the end, the book summarizes the ethical and legal challenges posed by AI in healthcare and biomedical research. This book is an invaluable source for researchers, medical and industry practitioners, academicians, and students exploring the applications of AI in biomedical research and healthcare.

• List of Contributors ix Preface xi
• 1 Ecosystems Function Like Interlocking Puzzles: Visually Interpreting the Concept of Niche Space Plus a Brief Tour Through Genetic Hyperspace 1 Christon J. Hurst
• 2 Human and Climatic Drivers of Harmful Cyanobacterial Blooms (CyanoHABs) 31 Hans W. Paerl
• 3 Biodegradation of Environmental Pollutants by Autochthonous Microorganisms - A Precious Service for the Restoration of Impacted Ecosystems 49 Joana P. Fernandes, Diogo A. M. Alexandrino, Ana P. Mucha, C. Marisa R. Almeida, and Maria F. Carvalho
• 4 Early Biofilm Accumulation in Freshwater Environments on Different Types of Plastic 83 Rene Hoover, Carlos De Leon, and Mark A. Gallo
• 5 Identification of Sentinel Microbial Communities in Cold Environments 107 Eva Garcia-Lopez, Paula Alcazar, Marina Alcazar, and Cristina Cid
• 6 Analyzing Microbial Core Communities, Rare Species, and Interspecies Interactions Can Help Identify Core Microbial Functions in Anaerobic Degradation 127 Tong Liu, Xavier Goux, Magdalena Calusinska, and Maria Westerholm
• 7 Role of Microbial Communities in Methane and Nitrous Oxide Fluxes and the Impact of Soil Management 159 Alessandra Lagomarsino and Roberta Pastorelli
• 8 Impact of Microbial Symbionts on Fungus-Farming Termites and Their Derived Ecosystem Functions 185 Robert Murphy, Veronica M. Sinotte, Suzanne Schmidt, Guangshuo Li, Justinn Renelies-Hamilton, N'Golo A. Kone, and Michael Poulsen
• 9 The Ecosystem Role of Viruses Affecting Eukaryotes 211 Christon J. Hurst Index 269.
• (source: Nielsen Book Data)

Assessing the Microbiological A timely exploration of the coordinated functions of microbiological communities and the impacts of global climate change on microbial life Ecosystems function like interlocking puzzles and ultimately the health of an ecosystem depends upon the niche activities of its microbial communities. Assessing the Microbiological Health of Ecosystems summarizes our understanding of how microbial community processes are organized and the mechanisms by which activities of their constituent species are coordinated. The authors collectively present a basis for understanding what produces healthy microbial components of an ecosystem, thereby supplying a foundation for achieving one of the eventual future goals of environmental microbiology: to diagnose and correct the integrative nature of microbial activities when ecosystems fail. Assessing the Microbiological Health of Ecosystems will prove to be a valuable resource to environmental microbiologists, ecologists and integrative biologists. The book will: help researchers and students to understand the commonalities of processes, techniques, and discoveries in the study of microbial communities contribute to understandings of how microbial communities coordinate their function, discussing how the relative rates and effective integration of community microbial processes are currently measured provide insights into the composition of a healthy microbial ecosystem By learning to recognize what constitutes and produces a healthy microbial ecosystem, we gain significant ground on the path towards being able to diagnose and correct the health of ailing microbial ecosystems. Assessing the Microbiological Health of Ecosystems will help new generations of scientists discern new ways to carry these efforts forward.
(source: Nielsen Book Data)

• 1. Bacterial physiology and biochemistry
• 2. Bacterial chemical composition and functional cell structures
• 3. Bacterial nutrition and growth
• 4. The processes of cell differentiation
• 5. Bacterial metabolism
• 6. Growth of microorganisms in nature
• 7. Impact of environmental factors on bacterial cells.
• (source: Nielsen Book Data)

Bacterial Physiology and Biochemistry provides the most current, authoritative, and relevant presentation of bacterial physiology and biochemistry on subject, chemical composition and functional bacterial cell structure, nutrition and growth, the process of cell differentiation, metabolism and the influence of environmental factors. The book helps the reader learn and obtain modern knowledges on bacterial physiology and biochemistry, including chemical composition and functional cell structures, bacterial nutrition and growth, and the processes of cell differentiation, bacterial metabolism and microbial growth in nature, and the effect of environmental factors on bacterial cells. This book is an educational resource designed for use in advanced bachelor's and master's courses in biology, including microbiology, biochemistry and molecular biology. It contains curriculum taught to biology students specializing in microbiology.
(source: Nielsen Book Data)

• Intro
• Preface
• Introduction
• Acknowledgements
• Abbreviations
• Contents
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• References
• List of Eponimous Syndromes/Diseases/ Tests/Cells From A to Z
• List of Names and Eponimous Syndrome/Disease/Object From A to Z

Hundreds of eponyms are used within the field of immunologyPetri dish, Crohns disease, Bence Jones protein, Kupffer cells, Freund's adjuvant, Ouchterlony immunodiffusion, to name just a fewbut most of us don't know much about the individuals who gave their names to these terms. Where were they born and educated, what other accomplishments are they credited with, why has history chosen to remember them, or not? This book presents the first comprehensive collection of immunologic eponyms, and through them tells the story of this fascinating field, from its earliest beginnings to present day. Organized by surname and meticulously cross-referenced and indexed, this book offers historical anecdotes and little-known facts which scientists, clinicians, students, and general readers will find captivating and memorable. A one-of-a-kind introduction to immunology that serves as both a history lesson and current reference on the diseases, treatments, and individuals who have been crucial to this field.

• Chapter 1: The world of microorganisms
• Chapter 2: The dawn of microbiology
• Chapter 3: Communication between microorganisms
• Chapter 4: Microbial communities
• Chapter 5: Gene transfer
• Chapter 6: Multidrug resistant bacteria
• Chapter 7: Synthetic biology in microbiology
• Chapter 8: Artificial intelligence in microbiology
• Chapter 9: Emerging and zoonotic diseases
• Chapter 10: COVID-19
• Chapter 11: Future pandemics
• Chapter 12: Into a brighter future.

Recent discoveries in microbiology are hard to grasp for those unfamiliar with scientific jargon, and the research data can be overwhelming even for those working in other scientific fields. This book aims to remedy this situation by presenting the most interesting findings and current trends in microbiology in an easy-to-read and understandable format. The first part tells the story of the beginnings of microbiology itself and introduces the reader to the founders of this fascinating research discipline. The second part focuses on communication between microorganisms and how they organize themselves into fascinating microbial cities called "biofilms". The reader also learns how bacteria exchange genetic material - mechanisms that are the root of the emergence of multidrug-resistant superbugs, pathogens that pose a major burden to human health and our healthcare systems. The third part is devoted to the latest techniques being used by scientists to study, control, and manipulate microorganisms for our benefit. The final part links the first three parts together and highlights how infectious diseases, including coronaviruses, can be transmitted from animals to humans, how global warming is affecting emerging diseases, and provides information on the actions that need to be taken to get ahead of pathogenic microbes and future pandemics. This comprehensive, state-of-the-art book is intended for anyone interested in microbiology and epidemiology, from biology and biomedical students in schools and colleges, to patients suffering from infectious diseases who want to learn more about their condition. The concepts covered in this book contribute to UN Sustainable Development Goal 3: Health and Well-Being.

• See Attachments.
• (source: Nielsen Book Data)

This book offers an analytical look at the much debated risks and benefits of the newly developed COVID-19 mRNA-vaccines. As such, it is one of the first books to give a comprehensive overview of mRNA vaccines against COVID-19 and the only one that addresses this topic from a broad multidisciplinary background. It brings together insights from various underlying disciplines on the challenges of developing and evaluating the most suitable vaccines for mass vaccination programs enrolled throughout the world - focusing on safety and efficacy. This book should not be missing on the shelf of any biomedical researcher, epidemiologist, public health professional or clinical researcher interested in SARS-CoV2 or virology and vaccine development in general. .
(source: Nielsen Book Data)

• A Surgical Approach to Hindlimb Suspension: A Mouse Model of Disuse-Induced Atrophy
• Remote Ischemic Pre-Conditioning (RIPC)
• Mouse Corneal Transplantation
• Analysis of Chemokine-to-GAG Interactions in Model of Donor Renal Allograft Transplant
• Mouse Models of Renal Allograft Transplant Rejection: Methods to Investigate Chemokine:GAG Interaction and Therapeutic Blockade
• Ex Vivo Perfusion System to Analyze Chemokine-Driven Leukocyte Adhesion
• In Vitro (Trans)migration Experiment Using Chemokines as Stimulatory Factor
• The Use of Campenot Trichambers for the Study of Peripheral Neuronal Growth and Survival in Presence of Thrombotic Factors and Serpins
• Flow Cytometry Analysis of Immune Cell Responses
• Detection of Chemokine Binding Proteins Association to Cell Surface Glycosaminoglycans by Flow Cell Cytometry and Indirect Immunofluorescence
• Protein Microarrays and Their Fabrication
• NMR Methods for Characterization of Glycosaminoglycan-Chemokine Interactions
• Glycosaminoglycan Analysis: Purification, Structural Profiling, and GAG-Protein Interactions
• Isolation and Compositional Analysis of Glycosaminoglycans
• How to Design Peptides
• Methods to Assess Chemokine Binding and Anti-Chemotactic Activity of Virus Proteins
• Producing Biologics with Defined N-Glycosylation in Plants
• Native Deglycosylation and Size Exclusion Chromatography of Viral Chemokine Binding Proteins for Structural Discovery.

This detailed volume provides methods to guide assay development, procedures designed to investigate the chemokine and glycosaminoglycan (GAG) networks, as well as their interactions, in a wide range of organs and tissues in disease and in health. The initial chapters in this book present in vivo models used to examine the roles of chemokines and GAGs in normal physiology and in the pathophysiology of disease. The book then explores present cell- and tissue-based in vitro assays to examine chemokine:GAG interactions. Finally, analytic approaches are presented that provide assays for measuring GAGs, chemokines, and cellular responses. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Chemokine-Glycosaminoglycan Interactions: Methods and Protocols serves as an ideal guide for researchers seeking to analyze chemokine and GAG functions, interactions, and molecular mechanisms in vivo and in vitro.

• 1. Microbial Responses under Climate Change Scenarios: Adaptation and Mitigations
• 2. Microbial Manipulation for Reduced Greenhouse Gas Emissions
• 3. Biogeochemical Processes and Climatic Change
• 4. Seasonal Dynamics of Bacterial and Fungal Lineages in Extreme Environments
• 5. Antimicrobial Resistance, Climate Change, and Public Health
• 6. Factors Responsible for Spatial Distribution of Enzyme Activity in Soil
• 7. Exploration of Bacterial Siderophores for Sustainable Future
• 8. Forest Cuttings and Their Impact on Edaphic and Regeneration Performance of Tree Species in the Temperate Forests of Kashmir Himalaya
• 9. Assessment of Standing Biomass, Forest Structure, and Edaphic Properties in the Temperate Forest of Kashmir Himalaya
• 10. Rapidly Changing Environment and Role of Microbiome in Restoring and Creating Sustainable Approaches.
• (source: Nielsen Book Data)

The ongoing global climate change triggered by greenhouse gas growth has had a significant effect on the microbial dynamics of plants and soils. This volume explores the various microbial responses of plants and soils caused directly or indirectly by climate change resulting from rising greenhouse gases and other factors. The book considers the rapidly changing environment and the important role of microbiomes in restoring soil and plant health and in creating sustainable approaches. It discusses the adaptation and mitigation of plants and soils, specifically addressing such topics as biogeochemical processes, antimicrobial resistance, the dynamics of bacteria and fungus in extreme environments, bacterial siderophores for sustainability, and more. The volume also looks at edaphic and regeneration performance of tree species in the temperate forests.
(source: Nielsen Book Data)

• Antibody sequence and structure analyses using IMGTª: 30 years of immunoinformatics
• Structural Classification of CDR-H3 in Single-Domain VHH Antibodies
• Computational modelling of Antibody and T Cell receptor (CDR3 loops)
• Molecular dynamics simulation for investigating antigen-antibody interaction
• Molecular Dynamics Methods for Antibody Design
• Probing antibody dynamics with geometric simulations
• PITHA: a webtool to predict immunogenicity for humanized and fully human therapeutic antibodies
• Thermal Stability Estimation of Single Domain Antibodies Using Molecular Dynamics Simulations
• Assessing and engineering antibody stability using experimental and computational methods
• In Silico Prediction Method for Protein Asparagine Deamidation
• Structure-based Optimization of Antibody-Based Biotherapeutics for Improved Developability: A Practical Guide for Molecular Modelers
• B-cell epitope predictions using computational methods
• Computational Epitope Prediction and Design for Antibody Development and Detection
• Information-driven antibody-antigen modelling with HADDOCK
• Structural modeling of adaptive immune responses to infection
• Protein-Protein Interaction Modelling with the Fragment Molecular Orbital Method
• Structural Considerations in Affinity Maturation of Antibody-Based Biotherapeutic Candidates
• Structure-based affinity maturation of antibody based on double-point mutations
• Antibody affinity maturation using computational methods: from an initial hit to small scale expression of optimised binders
• Optimizing Antibody-Antigen Binding Affinities with the ADAPT Platform
• Using graph-based signatures to guide rational antibody engineering
• A computational framework for determining the breadth of antibodies against highly mutable pathogens
• Analytical method for experimental validation of computer-designed antibody
• Computational analysis of antibody paratopes for antibody sequences in antibody libraries
• Bioinformatic Analysis of Natively Paired VH:VL Antibody Repertoires for Antibody Discovery
• Analyzing antibody repertoire using next-generation sequencing and machine learning
• A computational pipeline for predicting cancer neoepitopes. .

This volume details state-of-the- art methods on computer-aided antibody design. Chapters guide readers through information on antibody sequences and structures, modeling antibody structures and dynamics, prediction and optimization of biological and biophysical properties of antibodies, prediction of antibody-antigen interactions, and computer-aided antibody affinity maturation and beyond. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Computer-Aided Antibody Design aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge. Chapter 2 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

• Introduction.- Coronaviruses: history and viral properties.- Vaccine technologies, approaches against COVID-19, clinical phases.- Attenuated live vaccines.- Vector vaccines and virus-like particles.- Inactivated vaccines.- Recombinant proteins (protein subunits).- Nucleic acid-based vaccines.- Other aspects - One vaccine for all? - Herd immunity - Duration of immunity - Sterilizing immunity.- Summary.
• (source: Nielsen Book Data)

This book presents the principle, strengths and weaknesses, and progress of various vaccine technologies against COVID-19. Additionally, important terms such as clinical phases, efficacy and sterilizing immunity are explained. In this second edition, the already approved vaccines are also presented and the importance of viral variants is explained.
(source: Nielsen Book Data)

• Introduction, background and properties of coronaviruses
• Vaccine technologies, approaches against COVID-19, clinical phases
• Live vaccines, vector vaccines and virus-like particles
• Inactivated vaccines and recombinant protein
• Nucleic acid-based vaccines
• Other aspects : immunity and viral mutations
• Summary and outlook

"This book presents the principle, strengths and weaknesses, and progress of various vaccine technologies against COVID-19. Additionally, important terms such as clinical phases, efficacy and sterilizing immunity are explained. In this second edition, the already approved vaccines are also presented and the importance of viral variants is explained"-- Provided by publisher

• Origin, Phenotype, and Function of Mouse Dendritic Cell Subsets
• Phenotypes and Functions of Human Dendritic Cell Subsets Particularly in the Tumor Microenvironment
• In Vivo Tracking of Dendritic Cell Migration
• In Vivo Analysis of Dendritic Cell Clonality
• In Vitro Generation of Murine Bone Marrow-Derived Dendritic Cells
• In Vitro Generation of Murine Dendritic Cells from Hoxb8-Immortalized Hematopoietic Progenitors
• In Vitro Generation of Murine CD8α+ DEC205+ XCR1+ Cross-Presenting Dendritic Cells from Bone Marrow-Derived Hematopoietic Progenitors
• In Vitro Generation of Human Dendritic Cell Subsets from CD34+ Cord Blood Progenitors
• In Vitro Generation of Human Cross-Presenting Type 1 Conventional Dendritic Cells (cDC1s) and Plasmacytoid Dendritic Cells (pDCs)
• Culture System Allowing the Simultaneous Differentiation of Human Monocytes into Dendritic Cells and Macrophages Using M-CSF, IL-4, and TNF-a
• Clonal Analysis of Human Dendritic Cell Progenitors Using a Stromal Cell Culture
• Enrichment of Large Numbers of Splenic Mouse Dendritic Cells after Injection of Flt3L-Producing Tumor Cells
• Isolation and Identification of Dendritic Cell Subsets from Human and Mouse Tumors
• Optimized Non-Viral Gene Disruption in Primary Murine and Human Myeloid Cells
• Monitoring the Interaction between Dendritic Cells and T Cells In Vivo with LIPSTIC
• Characterization of Dendritic Cell Metabolism by Flow Cytometry
• In Vivo and In Vitro Assay to Address Dendritic Cells Antigen Cross-Presenting Capacity
• Assays to Detect Cross-Dressing by Dendritic Cells In Vivo and In Vitro
• Assessing the Ability of Human Dendritic Cells to Stimulate Naive CD4+ and CD8+ T Cells
• In Vitro and In Vivo Assays to Evaluate Dendritic Cell Phagocytic Capacity
• Tracking Plasmacytoid Dendritic Cell Response to Physical Contact with Infected Cells
• Harnessing Single Cell RNA Sequencing to Identify Dendritic Cell Types, Characterize Their Biological States, and Infer Their Activation Trajectory
• Characterization of Developmental Trajectories of Dendritic Cell Hematopoiesis through Single Cell RNA Sequencing Methods.

This detailed volume provides methods that can be used to study dendritic cell (DC) ontogeny, isolation, migration, and functions. After an introduction to murine and human DC subsets and their unique transcriptional, phenotypic, and functional properties, the book continues with sections covering in vivo studies, in vitro differentiation, enrichment, functional characterization, as well as Omics approaches to study dendritic cells. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Dendritic Cells: Methods and Protocols is an ideal guide to familiarize readers with the current state of the art techniques to investigate these vital cells.

• Preface
• Part I: On the Origin of Plagues 1. Parasites, Pathogens and the Tree of Life ; 2. The Red Queen and the Court Jester ; 3. Heirlooms and Souvenirs ; 4. New Alliances and Painful Scars
• Part II: The Ghosts of Plagues Past. 5. Medieval Outcasts ; 6. Cryptic Plagues ; 7. Disease Conquests ; 8. Conquering Diseases
• Part III: Emergence. 9. Heavy Harvests ; 10. Going Global ; 11. Tipping Points
• Epilogue: One Health and the Mad Hatter

"This book invites the reader to explore the chains of improbable events that can mold a long unknown pathogen into an agent of distress and tragedy for humanity"-- Provided by publisher

Nutrition is an important environmental factor for the maturation of the human immune system and essential for maintaining immunological homeostasis. Based on this, a variety of food applications with medical claims are being generated by food manufacturers worldwide in order to expand the market potential of products creating interesting linkages with other market segments, such as cosmetics and pharmaceuticals. However, in addition to the health benefits, active principles of such components often remain unexplored. This book focusses on the specific interactions between food ingredients and the immune system along the entire immune defense response. Starting from the immune barrier, through the innate and adaptive immune response, to active limitation and termination, all major mechanisms of the immune response are addressed and different biochemical, cellular and genetic interactions of components of our diet are discussed. The book presents a wealth of disease patterns for which nutritional factors are relevant and thereby provides indications for potential intervention strategies. In addition, associated food-technological aspects are discussed. Being the first of its kind, this book provides an overview of the variety of functional food components and their influence on immunological responses. Written in an accessible style, it addresses researchers, health professionals and students with different scientific backgrounds.
(source: Nielsen Book Data)