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"The Cell Biology of Inositol Lipids and Phosphates" is the published proceedings of the Biochemical Society's Annual Symposium held at the University of Birmingham on 29-31 March 2006, which featured presentations from international experts from across the field of cell signalling who have contributed to this volume. This meeting honoured Professor Bob Michell in recognition of his substantial contribution to the field.
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• Microbial diversity in the era of genomics / R. R. Colwell
• Patterns in prokaryotic biodiversity / M. C. Horner-Devine, J. Green, B. J. M. Bohannan
• A putative RNA-interference-based immune system in prokaryotes : the epitome of prokaryotic genomic diversity / E. V. Koonin ... et al.]
• The significance of prokaryote diversity in the human gastrointestinal tract / H. J. Flint
• The genetics of phenotypic innovation / H. J. E. Beaumont ... [et al.]
• Minimal genomes required for life / R. Gil, V. Perez-Brocal, A. Latorre, A. Moya
• Evolution of the core of genes / V. Daubin, E. Lerat
• Biogeographical diversity of archaeal viruses / K. M. Stedman, A. Clore, Y. Combet-Blanc
• Is there a link between chlamydia and heart disease? / L. A. Campbell, C.-C. Kuo
• Unculturable oral bacteria / W. G. Wade
• Comparative genomics - what do such studies tell us about the emergence and spread of key pathogens? / R. W. Titball, M. Duffield
• Spread of genomic islands between clinical and environmental strains / J. Klockgether, O. N. Reva, B. Tümmler
• Evolving gene clusters in soil bacteria / A. Morningstar ... [et al.]
• Unusual micro-organisms from unusual habitats : hypersaline environments / A. Ventosa
• Genomic islands and evolution of catabolic pathways / S. Lacour, M. Gaillard, J. R. van der Meer
• Horizontal gene transfer and its role in the emergence of new phenotypes / A. M. Osborn.

The true extent of prokaryote diversity, encompassing the spectrum of variability among bacteria, remains unknown. Current research efforts focus on understanding why prokaryote diversification occurs, its underlying mechanisms, and its likely impact. The dynamic nature of the prokaryotic world, and continuing advances in the technological tools available make this an important area and hence this book will appeal to a wide variety of microbiologists. Its coverage ranges from studies of prokaryotes in specialized environmental niches to broad examinations of prokaryote evolution and diversity, and the mechanisms underlying them. Topics include: bacteria of the gastrointestinal tract, unculturable organisms in the mouth and in the soil, organisms from extreme environments, the diversity of archaea and their phages, comparative genomics and the emergence of pathogens, the spread of genomic islands between clinical and environmental organisms, minimal genomes needed for life, horizontal gene transfer, phenotypic innovation, and patterns and extent of biodiversity.
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• Investigations of the modular structure of bacterial promoters - S Busby and N Miroslavova How transcriptional and epigenetic programmes are played out on an individual mammalian gene cluster during lineage commitment and differentiation - D Higgs et al. MOZ fusion proteins in acute myeloid leukaemia - P Troke et al. Mechanistic studies of the mRNA transcription cycle - P Cramer Modulation of RNA polymerase core functions by basal transcription factor TFB/TFIIB - R Weinzierl et al. The relationship between higher order chromatin structure and transcription - W Bickmore and N Gilbert Specialized transcription factories - P Cook et al. A role for upstream binding factor in organising ribosomal gene chromatin - B McStay et al. Nutrient regulated gene expression in eukaryotes - R Reece et al. Chromatin remodelling factors and the maintenance of transcriptional states through DNA replication - P Varga Weisz and S Aligianni Nucleosome dynamics - T Owen Hughes et al. Convergence of the SUMO and MAP kinase pathways on the ETS-domain transcription factor Elk-1 - S Yang and A Sharrocks Non coding RNA in transcription initiation - A Akoulitchev et al. Activation by c Myc of transcription by RNA polymerases I, II and III R White et al. Both normal and polyglutamine expanded Ataxin 7 are components of TFTC type GCN5 histone acetyltransferase containing complexes - L Tora et al. Regulation of NF kB function - K Campbell and N Perkins The p53 response during DNA damage: impact of transcriptional function by cofactors - A Coutts and N La Thangue The modulation of WT1 transcription function by cofactors Stefan Roberts The RNA polymerase I transcription machinery - J Russell and J Zomerdijk Fluorescence resonance energy transfer as a method for dissecting in vivo mechanisms of transcriptional activation - M Green et al. Core promoter-selective RNA polymerase II transcription - P Gross and T Oelgeschlager.
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Gene transcription has remained at the forefront of modern biomedical science due to genome-sequencing projects, the renewed interest in the role of chromatin, the availability of high-resolution structures of key parts of the transcriptional machineries and new insights into the physiological role of transcription. This collection of reviews, based on presentations at the Biochemical Society's 2005 Annual Symposium, provides an overview of the current state of research into gene expression-mechanisms.
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• The role of microtubules in transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells By K.J. Palmer, P. Watson and D.J. Stephens Kinases regulating Golgi apparatus structure and function By C. Preisinger and F.A. Barr Phosphoinositides and membrane traffic at the trans-Golgi network By R.R. Choudhury, N. Hyvola and M. Lowe N-glycans as apical targeting signals in polarized epithelial cells By P. Urquhart, S. Pang and N.M. Hooper Defective kidney anion-exchanger 1 (AE1, Band 3) trafficking in dominant distal renal tubular acidosis (dRTA) By A.M. Toye Regulation of the clathrin-coated vesicle by reversible phosphorylation By A. Flett, S. Semerdjieva, A.P. Jackson and E. Smythe Single-molecule live-cell imaging of clathrin-based endocytosis By T. Kirchhausen, W. Boll, A. van Oijen and M. Ehrlich Membrane traffic to and from lysosomes By J.P. Luzio, P.R. Pryor, S.R. Gray, M. Gratian, R.C. Piper and N.A. Bright Dynamin I phosphorylation and the control of synaptic vesicle endocytosis By K.J. Smillie and M.A. Cousin Early endocytic Rabs: functional prediction to functional characterization By J.C. Simpson and A.T. Jones The 'lipid raft' microdomain proteins reggie-1 and reggie-2 (flotillins) are scaffolds for protein interaction and signalling By C.A.O. Stuermer and H. Plattner Spatial control of actin-based motility through plasmalemmal PtdIns(4,5)P2-rich raft assemblies By T. Golub and P. Caroni The conflicting role of brain cholesterol in Alzheimer's disease: lessons from the brain plasminogen system By M.D. Ledesma and C.G. Dotti Endocytosis and retrograde axonal traffic in motor neurons By K. Deinhardt and G. Schiavo Consequences of lipid raft association on G-protein-coupled receptor function By A. Becher and R.A.J. McIlhinney Functional role of lipid rafts in CD20 activity? By E. Janas, R. Priest and R. Malhotra Biophysics (and sociology) of ceramides By F.M. Goni, F.-X. Contreras, L.-R. Montes, J. Sot and A. Alonso Reversible - through calmodulin - electrostatic interactions between basic residues on proteins and acidic lipids in the plasma membrane By S. McLaughlin, G. Hangyas-Mihalyne, I. Zaitseva and U. Golebiewska Translocation of the cell-penetrating Tat peptide across artificial bilayers and into living cells By P. Curnow, H. Mellor, D.J. Stephens, M. Lorch and P.J. Booth Aggregation and fibrillization of prions in lipid membranes By J. Kazlauskaite and T.J.T. Pinheiro BAR domains and membrane curvature: bringing your curves to the BAR By J.L. Gallop and H.T. McMahon.
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"Lipids, Rafts and Traffic" is the published proceedings of the Biochemical Society's Annual Symposium held at BioScience2004 in July 2004. The book describes the endocytosis and exocytosis of proteins and lipids, focusing on the role and mechanism of action of lipid rafts and clathrin-coated vesicles in these processes. The role of lipids and rafts in cell signalling and in disease states is also described.
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• Preface
• 1. Isotopic-labelling methods for deciphering the function of uncultured micro-organisms M. Wagner and M. W. Taylor
• 2. Biofilms and metal geochemistry: the relevance of micro-organism-induced geochemical transformations L. A. Warren
• 3. Minerals, mats, pearls and veils: themes and variations in giant sulfur bacteria N. D. Gray and I. M. Head
• 4. Soil micro-organisms in Antarctic dry valleys: resource supply and utilization D. W. Hopkins, B. Elberling, L. G. Greenfield, E. G. Gregorich, P. Novis, A. G. O'Donnell and A. D. Sparrow
• 5. New insights into bacterial cell-wall structure and physico-chemistry: implications for interactions with metal ions and minerals V. R. Phoenix, A. A. Korenevsky, V. R. F. Matias and T. J. Beveridge
• 6. Horizontal gene transfer of metal homeostasis genes and its role in microbial communities of the deep terrestrial subsurfaces J. Coombs and T. Barkay
• 7. Biosilicification: the role of cyanobacteria in silico sinter deposition L. G. Benning, V. Phoenix and B. W. Mountain
• 8. Metabolic diversity in the microbial world: relevance to exobiology K. H. Nealson and R. Popa
• 9. Biogeochemical cycling in polar, temperate and tropical coastal zones: similarities and differences D. B. Nedwell
• 10. Fungal roles and function in rock, mineral and soil transformations G. M. Gadd, M. Fomina and E. P. Burford
• 11. The deep intraterrestrial biosphere K. Pedersen
• 12. Iron, nitrogen, phosphorus and zinc cycling and consequences for primary productivity in the oceans J. A. Raven, K. Brown, M. Mackay, J. Beardall, M. Giordano, E. Granum, R. C. Leegood, K. Kilminster and D. I. Walker
• 13. Mechanisms and environmental impact of microbial metal reduction J. R. Lloyd
• 14. New insights into the physiology and regulation of the anaerobic oxidation of methane M. Kruger and T. Treude
• 15. Biogeochemical roles of fungi in marine and estuarine habitats N. Clipson, E. Landy and M. Otte
• 16. Role of micro-organisms in karstification P. C. Bennett and A. S. Engel.
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There is growing awareness that important environmental transformations are catalysed, mediated and influenced by microorganisms, and geomicrobiology can be defined as the influence of microorganisms on geologic processes. This is probably the most rapidly growing area of microbiology at present, combining environmental and molecular microbiology together with significant areas of mineralogy, geochemistry and hydrology. This volume focuses on the function of microorganisms in the environment and their influence on 'global' processes. It will include state-of-the art approaches to visualisation, culture and identification, community interactions and gene transfer, and diversity studies in relation to key processes. This overview for researchers and graduate students will represent environmental microbiology in its broadest sense and help to promote exciting collaborations between microbiologists and those in complementary physical and chemical disciplines.
(source: Nielsen Book Data)

• Preface
• 1. Adaptive immune responses J. L. Whitton
• 2. T-cell responses and dengue haemorrhagic fever G. Screaton and J. Mongkolsapaya
• 3. The immune response to human immunodeficiency virus type 1 (HIV-1) E. Turnbull and P. Borrow
• 4. Persistent RNA virus infections C. M. Dixon, L. Breakwell, G. Barry and J. K. Fazakerley
• 5. Exotic virus pathogenesis S. Nichol
• 6. Molecular approaches to the pathogenesis of feline coronaviruses C. Dye and S. Siddell
• 7. The transmissible spongiform encephalopathies J. C. Manson and R. M. Barron
• 8. Influenza virus pathogenicity R. G. Webster, A. S. Lipatov and E. Hoffmann
• 9. RNAi as an antiviral mechanism and therapeutic approach R. P. van Rij and R. Andino
• 10. Neurons and host immunity conspire to maintain herpes simplex virus in a latent state M. L. Freeman, V. Decman and R. L. Hendricks
• 11. Hepatitis C virus disruption of interferon signalling pathways and evasion of innate intracellular antiviral defences S. M. Lemon and K. Li
• 12. Human papillomaviruses and their effects on cell cycle control and apoptosis L. Gray, C. Jolly and C. S. Herrington
• 13. Intracellular antiviral defence mechanisms: the power of interferon-regulated restriction factors O. Haller, F. Weber and G. Kochs
• 14. Poxvirus immune evasion A. Alcami
• 15. Evasion of host defence systems by African swine fever virus L. K. Dixon
• 16. Murid herpesvirus 4 as a model for gammaherpesvirus pathogenesis J. P. Stewart, D. Hughes, L. Roaden and B. Ebrahimi
• Index.
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Virus and prion diseases remain a major public health threat, in both developed and developing countries. The worldwide HIV pandemic is but one example of a newly emerged virus disease; other potential threats come from exotic viruses such as SARS, Ebola and Hantaan viruses. Older human viruses such as influenza, papilloma, herpes and the hepatitis viruses still cause major health problems. Furthermore, as well as causing acute infections, some viruses may also establish persistent infections which can lead to the development of chronic diseases, including cancer. This symposium book covers central factors that influence the pathogenicity of virus and prion infections. Topics range from innate and adaptive immune responses and virus evasion of host defences to details of selected virus host interactions, including those involving dengue virus, HIV, influenza viruses, coronaviruses, hepatitis C virus, herpesviruses, papillomaviruses, African swine fever virus and poxviruses.
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'Free Radicals: Enzymology, Signalling and Disease' is the published proceedings of the Biochemical Society's Annual Symposium held at the University of Essex in July 2003. It aims to provide an overview of research in free radical biochemistry from a variety of perspectives.
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• Preface
• 1. Vector-borne diseases B. W. J. Mahy
• 2. Evolution of tick-borne disease systems S. E. Randolph
• 3. Insect transmission of viruses S. Blanc
• 4. Interactive silencing of host gene expression S. W. Ding
• 5. Reducing the prevalence of Borrelia in ticks A. G. Barbour
• 6. Bunyavirus/mosquito interactions R. M. Elliott
• 7. How do mosquito vectors live with their viruses? S. Higgs 8. Induction of vector competence S. Weaver
• 9. Environmental influences on arbovirus infections and vectors P. S. Mellor
• 10. Vector immunity N. A. Ratcliffe and M. M. A. Whitten
• 11. Transmission of plant viruses by nematodes S. MacFarlane and D. J. Robinson
• 12. Wolbachia host-symbiont interactions M. J. Taylor
• 13. Pathogenic strategies of Anaplasma phagocytophilum, a unique bacterium that colonizes neutrophils J. A. Carlyon and E. Fikrig
• 14. Interactions of Yersinia pestis with its flea vector that lead to the transmission of plague B. J. Hinnebusch
• 15. Transgenic malaria P. W. Atkinson
• 16. Vaccines targeting vectors G. A. T. Targett
• Index.
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Several billion people are at daily risk of life threatening vector-borne diseases such as malaria, trypanosomiasis and dengue. This volume describes the way in which the causal pathogens of such diseases interact with the vectors that transmit them. It details the elegant biological adaptations that have enabled pathogens to live with their vectors and, in some circumstances, to control them. This knowledge has led to novel preventative strategies in the form of antibiotics and new vaccines which are targeted not at the pathogen itself but at its specific vector.
(source: Nielsen Book Data)

• Preface
• 1. The structure of the enteropathogenic Escherichia coli type III-secretion apparatus Elizabeth A. Creasey and Gad Frankel
• 2. Vaccinia virus movement in cells Geoffrey L. Smith
• 3. Induction of pro-inflammatory signals by Salmonella-epithelial cell interactions Abigail N. Blakey and Edouard E. Galyov
• 4. Modulation of Toll-like receptor signalling by viruses Andrew Bowie
• 5. Enteropathogenic Escherichia coli (EPEC) and its effector molecules Brendan Kenny and Jonathan Warawa
• 6. Lipid-protein interactions in enveloped virus entry, protein traffic, and assembly Min Li, Andrei N. Vzorov, Armin Weidmann, Chinglai Yang and Richard W. Compans
• 7. Legionella pneumophila: a model system to study bacterial modulation of phagosome transport Craig R. Roy
• 8. Regulation of membrane fusion processes in eukaryotic cells: what can we learn from pathogenic mycobacteria? Jean Pieters
• 9. Molecular and cellular mechanisms of action of the VacA and HP-NAP virulence factors of Helicobacter pylori Marina de Bernard and Cesare Montecucco
• 10. Who is controlling the inflammatory response in shigellosis - bacteria or host? Jonathan D. Edgeworth and Philippe J. Sansonetti
• 11. Cell death on demand: herpes simplex viruses and apoptosis Joshua Munger, Guoying Zhou and Bernard Roizman
• 12. Apoptosis in Shigella and Salmonella infections Volker Brinkmann and Arturo Zychlinsky
• 13. Setting up a nest and maintaining it: intracellular replication of Legionella pneumophila Ralph R. Isberg
• 14. Entry of Listeria monocytogenes into mammalian cells: from cell biology to physiopathology P. Cossart
• Index.
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Microbes have co-evolved with other organisms for eons, to the extent that some are so acquainted with host cell biology that they subvert key cellular processes with unrivalled precision. Pathogenic bacteria and viruses, for example, are extremely adept at intercepting host signal transduction pathways, re-routing protein traffic, remodelling the cytoskeleton and influencing host cell differentiation or death. Symbionts and commensal organisms, too, have evolved sophisticated strategies to derive benefit from the host environment without eliciting responses that compromise their viability. This volume reviews this exciting new discipline, reflecting both the recent explosion of knowledge and the wider insights into fundamental cellular processes that are provided. The authors, chosen for their contributions to the field, cover all the salient aspects using a range of model systems.
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• Structural basis of matrix metalloproteinase function
• papain-like lysosomal cysteine proteases and their inhibitors - drug discovery targets?
• roles for asparagine endopeptidase in class II MHC-restricted antigen processing
• substrate specificity and inducibility of TACE revisited - Ala-Val preference and induced intrinsic activity
• meprin proteolytic complexes at the cell surface and in extracellular spaces
• roles of TIMPs in pericellular proteolysis - the specificity is in the detail
• collagen-platelet interactions - recognition and signalling
• control of the expression of inflammatory response genes
• use of anti-neoepitope antibodies for the analysis of degradative events in cartilage and the molecular basis for neoepitope specificity
• proteolysis of the collagen fibril in osteoarthritis
• cytokine synergy, collagenases and cartilage collagen breakdown
• proteolytic "defences" and the accumulation of oxidized polypeptides in cataractogenesis and atherogenesis
• proteases as drug targets
• how serpins change their shape for better and for worse
• cystatins
• designing TIMP variants that are selective metalloproteinase inhibitors
• memapsin 2, a drug target for Alzheimer's disease
• control of lipid metabolism by regulated intramembrane proteolysis of SREBPs
• caspase activation
• separase regulation during mitosis
• membrane-type 1 matrix metalloproteinase and cell migration
• cathepsin B and its role(s) in cancer progression
• proteolytic and non-proteolytic migration of tumour cells and leucocytes.
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This title is the published proceedings of the Biochemical Society meeting held at Imperial College London in December 2002. The meeting brought together international leaders in the field to discuss contemporary advances in protease research and was dedicated to Dr Alan J Barrett to honour his research achievements and contributions to the field of proteolytic enzymes on his 65th birthday. This book aims to provide an overview of contemporary research on the roles of proteolytic enzymes in biological systems. Contributions come from some of the leading scientists in this field and cover areas such as the proteasome and antigen presentation; extracellular and pericellular proteolysis; inflammation and tissue destruction; protease inhibitors and potential for therapy; intracellular proteolysis and apoptosis; and proteolysis and cell migration.
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Sugars that decorate the surfaces of proteins and cells represent a unique form of information that is used in communication both within and between cells. The science of glycobiology examines the roles of these glycans in protein trafficking, cell-cell adhesion, organization of the extracellular matrix, signalling and other processes. Because sugars are not encoded directly in genomes, the enzymes that assemble complex oligosaccharides, and the lectins that recognize them, provide essential links between genomes and glycobiology. The availability of complete genome sequences provides an opportunity to take a global view of the field. This text focuses on what can be learned about the biological functions of glycans from the genomic analysis of lectins and biosynthetic enzymes. It explores special tactics that are needed to develop an overview of the glycans that are present in an organism and highlights both the advantages and limitations of working with simpler model organisms. The book illustrates not only what can be learned, but also provides speculation on how the field of glycobiology will develop in the future.
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In recent years, there has been an increased need for statistical information and population projections for the minority ethnic populations resident in Britain. This publication has been written by members of an expert group of academic demographers, geographers and other researchers specialising in quantitative demographic ethnicity. It considers the feasibility and advantages of population projections based on ethnicity; outlines how fertility, migration and mortality could be estimated for different minority ethnic populations; and discusses possible theoretical models that could be used to make these projections .
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• Editor's preface
• 1. Microbial reaction to environment: bacterial stress responses revisited in the genomic-proteomic era F. C. Neidhardt
• 2. Gene variation and gene regulation in bacterial pathogenesis D. Hood and R. Moxon
• 3. DNA topology and regulation of bacterial gene expression C. J. Dorman
• DNA rearrangements and regulation of gene expression I. C. Blomfield
• 4. Structures of multisubunit DNA-dependent RNA polymerases R. D. Finn, E. V. Orlova, M. van Heel and M. Buck
• 5. The ECF sigma factors of Streptomyces coelicolor A3(2) M. S. B. Paget, H-J. Hong, M. Bibb and M. J. Buttner
• 6. Secrets of bacterial transcription initiation taught by the Escherichia coli FNR protein D. Browning, D. Lee, J. Green and S. Busby
• 7. What can be learned from the LacR family of Escherichia coli? B. Muller-Hill
• 8. Regulation of the L-arabinose operon in Escherichia coli R. Schleif
• 9. Transcription termination control in bacteria T. M. Henkin
• 10. Antisense RNAs in programmed cell death K. Gerdes
• 11. Control of signal transduction in the sporulation phosphorelay J. A. Hoch
• 12. A stranglehold on a transcriptional activator by its partner regulatory protein - the case of the NifL-NifA two-component regulatory system R. Dixon
• 13. Is anybody here? Cooperative bacterial gene regulation via peptide signals between Gram-positive bacteria D. A. Morrison
• 14. Quorum sensing in Gram-negative bacteria: global regulons controlled by cell-density-dependent chemical signalling N. A. Whitehead, A. K. P. Harris, P. Williams and G. P. C. Salmond
• Index.
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DNA sequencing has provided a wealth of information on the genetic material stored in bacterial genomes. The use of DNA arrays and proteomics will transform the scale of our ability to describe the patterns of gene expression as bacteria respond to their environments. However, the ability to control bacteria in a clinical context or exploit them in industrial or environmental contexts also depends on understanding the regulatory mechanisms which connect input experience to output response at the genetic level. This book deals with our current knowledge of the circuits and networks that govern bacterial gene expression - from the single gene to the whole genome - and which provide the framework for explaining the data from the post genomics revolution.
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Cancer Trends from National Statistics brings together into one comprehensive reference source information of the cancer burden in England and Wales, making this report essential reading for cancer specialists, researchers and medical librarians. The report provides both summary and more detailed information on trends in cancer incidence, mortality, prevalence and survival at the national and regional levels during the second half of the last century. For example "Between 1950 and 1999, the proportion of deaths due to cancer rose from 15 to 27 per cent for males and from 16 to 23 per cent for females." The summary chapter ensures that readers who only require an overview can quickly access information on the incidence of and mortality from all malignant cancers for nine of the most important individual cancer sites; the prevalence of major cancers; and details of survival trends by age, sex and socio-economic deprivation. Researchers will then benefit from the reports detailed results on incidence, mortality, prevalence and survival which are presented in 20 separate chapters for each of the main cancer sites which together constitute almost 90 per cent of all malignancies in both males and females. Each chapter also includes a brief description of the epidemiology of the particular cancer, its global significance, known or suspected causes, risk factors and treatment. Cancer trends also features a chapter on several types of childhood cancer which together constitute 82 per cent of all childhood cancers. (Incidence figures cover the period 1971-97 and figures for the last three years are provisional, but are reliable, being based on data from half of the regional cancer registries in England and Wales. Mortality data cover the period 1950-99.).
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• The structural basis of protein folding and its links with human with human disease By C.M Dobson * Manipulating the folding of membrane proteins: using the bilayer to our advantage By P.J. Booth, A.R. Curran, R.H. Templer, H. Lu and W. Meijberg * Self-perpetuating changes in Sup35 protein conformation as a mechanism of heredity in yeast By T.R. Serio, A.G. Cashikar, A.S. Kowal, G.J. Sawicki and S.L. Lindquist * Contribution of molecular chaperones to protein folding in the cytoplasm of prokaryotic and eukaryotic cells By D.J. Naylor and F.-Y. Hartl * Defining the structure of the substrate-free state of the DnaK molecular chaperone By J.F. Swain, R. Sivendran and L.M. Gierasch * Validation of protein-unfolding transition states identified in molecular dynamics simulations By Valerie Daggett * Structure, stability and folding of the a -helix By A.J. Doig, C.D. Andrew, D.A.E. Cochran, E. Hughes, S. Penel, J.K. Sun, B.J. Stapley, D.T. Clarke, G.R. Jones * Guidelines for the assembly of novel coiled-coil structures: a-sheets and a -cylinders By J. Walshaw, J.M. Shipway and D.N. Woolfson * Protease inhibitors and directed evolution: enhancing plant resistance to nematodes By M.J. McPherson and D.J. Harrison * Degradation of explosives by nitrate ester reductases By R.E. Williams, D.A. Rathbone, P.C.E. Moody, N.S. Scrutton and N.C. Bruce.
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This volume offers a collection of articles written by speakers at the 68th Annual Symposium of the Biochemical Society held at the University of Leeds in April 2000. The articles present an up-to-date view of protein folding "in vitro" and "in vivo", the role of chaperones in folding, and the consequences of protein misfolding, for example in amyloid diseases. In addition, simulations of folding mechanisms, protein design principles, and protein engineering to produce novel enzymes are discussed. The chapters highlight successes in these areas, and point the way forward in these disciplines. The articles describe the biology of a yeast prion, using techniques spanning structural biology to yeast genetics to reveal how this protein can cause the inheritance of new traits and explains some of the amazing feats by which protein folding is chaperoned in cells. They also provide guidelines for the assembly of novel coiled-coil structures and highlights how environmental screening has been used to produce new enzymes capable of reducing nitrate esters and theire use in the degradation of explosives. In addition, the approaches of DNA shuffling and phage display and their use in the creation of evolved protease inhibitors and tackles the immensely complex biological and biophysical problem of how a membrane protein folds are examined.
(source: Nielsen Book Data)